{"id":239,"date":"2022-10-09T00:00:00","date_gmt":"2022-10-08T15:00:00","guid":{"rendered":"https:\/\/best-biostatistics.com\/toukei-er\/entry\/how-to-determine-sample-size-for-mmrm\/"},"modified":"2024-09-04T23:02:34","modified_gmt":"2024-09-04T14:02:34","slug":"how-to-determine-sample-size-for-mmrm","status":"publish","type":"post","link":"https:\/\/best-biostatistics.com\/toukei-er\/entry\/how-to-determine-sample-size-for-mmrm\/","title":{"rendered":"MMRM \u306b\u5fc5\u8981\u306a\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u3092\u884c\u3046\u65b9\u6cd5"},"content":{"rendered":"\n<p>MMRM\u306f\u3001Mixed Model with Repeated Measures\u306e\u7565\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u53cd\u5fa9\u6e2c\u5b9a\u306e\u9023\u7d9a\u30c7\u30fc\u30bf\u3092\u7dda\u5f62\u6df7\u5408\u30e2\u30c7\u30eb\u3067\u89e3\u6790\u3059\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u8a66\u9a13\u30fb\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u306e\u3068\u304d\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306f\u3069\u306e\u3088\u3046\u306b\u3057\u305f\u3089\u3088\u3044\u304b\uff1f<\/p>\n\n\n\n<!--more-->\n\n\n\n<h2 class=\"wp-block-heading\" id=\"MMRM\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u30b5\u30a4\u30c8\">MMRM\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u30b5\u30a4\u30c8<\/h2>\n\n\n\n<p>\u4ee5\u4e0b\u306e\u30b5\u30a4\u30c8\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u7528\u3044\u308b\u3068\u8a08\u7b97\u3067\u304d\u308b\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/nshi.jp\/contents\/js\/mmrm\/\">MMRM\u306b\u5bfe\u3059\u308b\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a2d\u8a08 | Kengo Nagashima &#8211; Keio University<\/a><\/p>\n\n\n\n<p>\u7406\u8ad6\u306f\u3055\u3066\u304a\u304d\u3001\u4f7f\u3044\u65b9\u306b\u7279\u5316\u3057\u3066\u3001\u7d39\u4ecb\u3057\u3066\u307f\u305f\u3044\u3068\u601d\u3046\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"MMRM-\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306e\u305f\u3081-\u30b5\u30f3\u30d7\u30eb\u30c7\u30fc\u30bf\u306fEZR\u516c\u5f0f\u30de\u30cb\u30e5\u30a2\u30eb\u304b\u3089\">MMRM \u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306e\u305f\u3081 \u30b5\u30f3\u30d7\u30eb\u30c7\u30fc\u30bf\u306fEZR\u516c\u5f0f\u30de\u30cb\u30e5\u30a2\u30eb\u304b\u3089<\/h2>\n\n\n\n<p>\u30b5\u30f3\u30d7\u30eb\u30c7\u30fc\u30bf\u306f\u3001EZR\u516c\u5f0f\u30de\u30cb\u30e5\u30a2\u30eb\u306e\u30c7\u30fc\u30bf\u306e\u4e00\u90e8\u3092\u629c\u7c8b\u3057\u3066\u4f7f\u7528\u3059\u308b\u3002<\/p>\n\n\n\n<p>EZR\u516c\u5f0f\u30de\u30cb\u30e5\u30a2\u30eb<\/p>\n\n\n\n<div class=\"hatena-asin-detail\"><a href=\"https:\/\/www.amazon.co.jp\/dp\/449810918X?tag=ttyotani-22&amp;linkCode=ogi&amp;th=1&amp;psc=1\" class=\"hatena-asin-detail-image-link\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/m.media-amazon.com\/images\/I\/51ouXcnW2-L._SL500_.jpg\" class=\"hatena-asin-detail-image\" alt=\"EZR\u3067\u3084\u3055\u3057\u304f\u5b66\u3076\u7d71\u8a08\u5b66 \u6539\u8a023\u7248 \u301cEBM\u306e\u5b9f\u8df5\u304b\u3089\u81e8\u5e8a\u7814\u7a76\u307e\u3067\u301c\" title=\"EZR\u3067\u3084\u3055\u3057\u304f\u5b66\u3076\u7d71\u8a08\u5b66 \u6539\u8a023\u7248 \u301cEBM\u306e\u5b9f\u8df5\u304b\u3089\u81e8\u5e8a\u7814\u7a76\u307e\u3067\u301c\"><\/a>\n<div class=\"hatena-asin-detail-info\">\n<p class=\"hatena-asin-detail-title\"><a href=\"https:\/\/www.amazon.co.jp\/dp\/449810918X?tag=ttyotani-22&amp;linkCode=ogi&amp;th=1&amp;psc=1\" target=\"_blank\" rel=\"noopener\">EZR\u3067\u3084\u3055\u3057\u304f\u5b66\u3076\u7d71\u8a08\u5b66 \u6539\u8a023\u7248 \u301cEBM\u306e\u5b9f\u8df5\u304b\u3089\u81e8\u5e8a\u7814\u7a76\u307e\u3067\u301c<\/a><\/p>\n<ul class=\"hatena-asin-detail-meta\">\n<li><span class=\"hatena-asin-detail-label\">\u4f5c\u8005:<\/span><a href=\"https:\/\/d.hatena.ne.jp\/keyword\/%BF%C0%C5%C4%20%C1%B1%BF%AD\" class=\"keyword\">\u795e\u7530 \u5584\u4f38<\/a><\/li>\n<li>\u4e2d\u5916\u533b\u5b66\u793e<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.amazon.co.jp\/dp\/449810918X?tag=ttyotani-22&amp;linkCode=ogi&amp;th=1&amp;psc=1\" class=\"asin-detail-buy\" target=\"_blank\" rel=\"noopener\">Amazon<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<p>\u8a08\u7b97\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u30b5\u30a4\u30c8\u3068\u540c\u3058\u304f\u3061\u3087\u3046\u30694\u56de\u306e\u53cd\u5fa9\u6e2c\u5b9a\u3067\u3042\u308b\u306e\u3067\u3001\u30c7\u30d5\u30a9\u30eb\u30c8\u8a2d\u5b9a\u304c\u305d\u306e\u307e\u307e\u4f7f\u3048\u308b\u3002<\/p>\n\n\n\n<div id=\"biost-2064933639\" class=\"biost- biost-entity-placement\"><p style=\"text-align: center;\"><span style=\"font-size: 20px;\"><strong><a href=\"https:\/\/best-biostatistics.com\/kmhl\">\uff1e\uff1e\u3082\u3046\u7d71\u8a08\u3067\u60a9\u3080\u306e\u306f\u7d42\u308f\u308a\u306b\u3057\u307e\u305b\u3093\u304b\uff1f\u00a0<\/a><\/strong><\/span><\/p>\r\n<a href=\"https:\/\/best-biostatistics.com\/kmhl\"><img class=\"aligncenter wp-image-2794 size-full\" src=\"https:\/\/best-biostatistics.com\/wp\/wp-content\/uploads\/2023\/11\/bn_r_03.png\" alt=\"\" width=\"500\" height=\"327\" \/><\/a>\r\n<p style=\"text-align: center;\"><span style=\"color: #ff0000; font-size: 20px;\"><strong><span class=\"marker2\">\u21911\u4e07\u4eba\u4ee5\u4e0a\u306e\u533b\u7642\u5f93\u4e8b\u8005\u304c\u8cfc\u8aad\u4e2d<\/span><\/strong><\/span><\/p><\/div><h2 class=\"wp-block-heading\" id=\"MMRM-\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306e\u524d\u63d0-1\u53cd\u5fa9\u6e2c\u5b9a\u76ee\u7684\u5909\u6570\u306e\u76f8\u95a2\u884c\u5217\">MMRM \u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306e\u524d\u63d0 1\uff1a\u53cd\u5fa9\u6e2c\u5b9a\u76ee\u7684\u5909\u6570\u306e\u76f8\u95a2\u884c\u5217<\/h2>\n\n\n\n<p>\u4e00\u756a\u6700\u521d\u306b\u7fa4\u5225\u306e\u76f8\u95a2\u884c\u5217\u3068\u3044\u3046\u306e\u304c\u76ee\u306b\u5165\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"555\" height=\"329\" src=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210703.png\" alt=\"\" class=\"wp-image-1378\" title=\"\" srcset=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210703.png 555w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210703-300x178.png 300w\" sizes=\"(max-width: 555px) 100vw, 555px\" \/><\/figure>\n\n\n\n<p><span itemscope=\"\" itemtype=\"http:\/\/schema.org\/Photograph\"><\/span><\/p>\n\n\n\n<p>\u3053\u308c\u306f\u3001\u53cd\u5fa9\u6e2c\u5b9a\u3057\u3066\u3044\u308b\u76ee\u7684\u5909\u6570\u540c\u58eb\u306e\u76f8\u95a2\u884c\u5217\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u5bfe\u89d2\u7dda\u4e0a\u306f\u540c\u3058\u6642\u70b9\u306e\u6e2c\u5b9a\u5024\u540c\u58eb\u306a\u306e\u3067\u76f8\u95a2\u4fc2\u6570\u306f\uff11\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u305d\u308c\u4ee5\u5916\u306f\u3001\u7570\u306a\u308b\u6642\u70b9\u540c\u58eb\u306e\u6e2c\u5b9a\u5024\u540c\u58eb\u306e\u76f8\u95a2\u4fc2\u6570\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u5b9f\u969b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u6642\u70b9\u3054\u3068\u306e\u76f8\u95a2\u306f\u3070\u3089\u3070\u3089\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"883\" height=\"127\" src=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210119.png\" alt=\"\" class=\"wp-image-1379\" title=\"\" srcset=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210119.png 883w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210119-300x43.png 300w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210119-768x110.png 768w\" sizes=\"(max-width: 883px) 100vw, 883px\" \/><\/figure>\n\n\n\n<p><span itemscope=\"\" itemtype=\"http:\/\/schema.org\/Photograph\"><\/span><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"889\" height=\"136\" src=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210134.png\" alt=\"\" class=\"wp-image-1380\" title=\"\" srcset=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210134.png 889w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210134-300x46.png 300w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210134-768x117.png 768w\" sizes=\"(max-width: 889px) 100vw, 889px\" \/><\/figure>\n\n\n\n<p><span itemscope=\"\" itemtype=\"http:\/\/schema.org\/Photograph\"><\/span><\/p>\n\n\n\n<p>\u3067\u3042\u308b\u304c\u3001\u8a08\u7b97\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u30b5\u30a4\u30c8\u306e\u4f8b\u306e\u3088\u3046\u306b\u3001\u6642\u70b9\u540c\u58eb\u306e\u76f8\u95a2\u306f\u540c\u3058\u3068\u307f\u306a\u3057\u3066\u9032\u3081\u308b\u3053\u3068\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u5f62\u3092 compound symmetry \uff08SPSS\u3067\u306f\u8907\u5408\u30b7\u30f3\u30e1\u30c8\u30ea\uff09\u3068\u547c\u3076\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"555\" height=\"329\" src=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210703-1.png\" alt=\"\" class=\"wp-image-1381\" title=\"\" srcset=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210703-1.png 555w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210703-1-300x178.png 300w\" sizes=\"(max-width: 555px) 100vw, 555px\" \/><\/figure>\n\n\n\n<p><span itemscope=\"\" itemtype=\"http:\/\/schema.org\/Photograph\"><\/span><\/p>\n\n\n\n<p>\u5b9f\u969b\u306e\u5024\u306f\u4e0a\u8a18\u306e\u3088\u3046\u306b\u30d0\u30e9\u30d0\u30e9\u306a\u306e\u3067\u3001\u305d\u308c\u304c\u308f\u304b\u308b\u5834\u5408\u306f\u3001\u305d\u306e\u30d0\u30e9\u30d0\u30e9\u3092\u4f7f\u3046\u3053\u3068\u3082\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u30d0\u30e9\u30d0\u30e9\u306e\u76f8\u95a2\u4fc2\u6570\u884c\u5217\u306e\u5834\u5408\u306f\u3001\u7121\u69cb\u9020 (unstructured) \u3068\u547c\u3070\u308c\u308b\u3002<\/p>\n\n\n\n<p>\u4eca\u56de\u306f\u3001\u30c7\u30d5\u30a9\u30eb\u30c8\u306e compound symmetry \u306e\u307e\u307e\u3067\u9032\u3081\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"MMRM-\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306e\u524d\u63d0-2\u6b20\u6e2c\u306e\u767a\u751f\u5272\u5408\">MMRM \u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306e\u524d\u63d0 2\uff1a\u6b20\u6e2c\u306e\u767a\u751f\u5272\u5408<\/h2>\n\n\n\n<p>\u6b21\u306b\u6c7a\u3081\u306a\u3044\u3068\u3044\u3051\u306a\u3044\u306e\u306f\u3001\u6b20\u6e2c\u306e\u5024\u304c\u767a\u751f\u3059\u308b\u5272\u5408\u3002<\/p>\n\n\n\n<p>\u975e\u6b20\u6e2c\u306e\u5272\u5408\u3068\u3042\u3063\u3066\u3001\u3069\u306e\u304f\u3089\u3044\u306e\u5272\u5408\u304c\u304d\u3061\u3093\u3068\u89b3\u6e2c\u3055\u308c\u308b\u304b\u3068\u3044\u3046\u6570\u5024\u3092\u5165\u308c\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"558\" height=\"152\" src=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210957.png\" alt=\"\" class=\"wp-image-1382\" title=\"\" srcset=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210957.png 558w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008210957-300x82.png 300w\" sizes=\"(max-width: 558px) 100vw, 558px\" \/><\/figure>\n\n\n\n<p><span itemscope=\"\" itemtype=\"http:\/\/schema.org\/Photograph\"><\/span><\/p>\n\n\n\n<p>\u30c7\u30d5\u30a9\u30eb\u30c8\u3067\u306f\u3001100%, 90%, 80%, 70%\u3068\u3060\u3093\u3060\u3093\u306b\u8131\u843d\u3057\u3066\u3044\u304f\u3053\u3068\u3092\u60f3\u5b9a\u3092\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u8131\u843d\u306f\u307b\u307c\u306a\u3044\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u308b\u306a\u3089\u3001\u5168\u90e8100% \u3068\u304b\u3001\u4e0b\u304c\u3063\u3066\u308290%\u3068\u304b\u3059\u308b\u3068\u3088\u3044\u3068\u601d\u3046\u3002<\/p>\n\n\n\n<p>\u3053\u3061\u3089\u3082\u30c7\u30d5\u30a9\u30eb\u30c8\u306e\u307e\u307e\u3067\u3044\u304f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"MMRM-\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306e\u524d\u63d0-3\u7fa4\u5225\u306e\u6a19\u6e96\u504f\u5dee\">MMRM \u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306e\u524d\u63d0 3\uff1a\u7fa4\u5225\u306e\u6a19\u6e96\u504f\u5dee<\/h2>\n\n\n\n<p>\u6b21\u306b\u5fc5\u8981\u306a\u60c5\u5831\u306f\u3001\u6a19\u6e96\u504f\u5dee\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u7fa4\u5225\u306e\u6a19\u6e96\u504f\u5dee\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u3069\u306e\u6e2c\u5b9a\u6642\u70b9\u3068\u3044\u3046\u3053\u3068\u3067\u3082\u306a\u304f\u3001\u3069\u306e\u6e2c\u5b9a\u6642\u70b9\u3082\u540c\u3058\u6a19\u6e96\u504f\u5dee\uff08\u5206\u6563\uff09\u304c\u524d\u63d0\u3068\u306a\u308b\u3002<\/p>\n\n\n\n<p>\u30b5\u30f3\u30d7\u30eb\u30c7\u30fc\u30bf\u306e\u7fa4\u5225\u30fb\u6642\u70b9\u5225\u76ee\u7684\u5909\u6570\u306e\u6a19\u6e96\u504f\u5dee\u3092\u8a08\u7b97\u3059\u308b\u3068\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u306a\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"791\" height=\"385\" src=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008211357.png\" alt=\"\" class=\"wp-image-1383\" title=\"\" srcset=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008211357.png 791w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008211357-300x146.png 300w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008211357-768x374.png 768w\" sizes=\"(max-width: 791px) 100vw, 791px\" \/><\/figure>\n\n\n\n<p><span itemscope=\"\" itemtype=\"http:\/\/schema.org\/Photograph\"><\/span><\/p>\n\n\n\n<p>FCZ0\u7fa4\u306f\u300119.7, 20.0, 17.1, 20.1\u3068\u3044\u3046\u3053\u3068\u306a\u306e\u3067\u3001\u5927\u4f5319\u304f\u3089\u3044\u3068\u3059\u308b\u3002<\/p>\n\n\n\n<p>FCZ400\u7fa4\u306f\u300118.7, 16.6, 22.8, 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itemtype=\"http:\/\/schema.org\/Photograph\"><\/span><\/p>\n\n\n\n<p>\u306a\u306e\u3067\u3001\u4e21\u65b9\u306b19\u3068\u5165\u308c\u308b\u3002<\/p>\n\n\n\n<p>\u5272\u4ed8\u6bd4\u306f\uff11\u306b\u3057\u3066\u304a\u304f\u3002<\/p>\n\n\n\n<p>\u7279\u5225\u306a\u7406\u7531\u304c\u306a\u3044\u9650\u308a\u3001\u5272\u4ed8\u6bd4\u306f\uff11\uff1a\uff11\u304c\u3082\u3063\u3068\u3082\u691c\u51fa\u529b\u304c\u9ad8\u304f\u671b\u307e\u3057\u3044\u305f\u3081\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"MMRM-\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306e\u524d\u63d0\uff14\u7fa4\u9593\u5dee\u6a19\u6e96\u504f\u5dee\u3092\uff11\u3068\u3059\u308c\u3070\u52b9\u679c\u91cf\">MMRM \u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306e\u524d\u63d0\uff14\uff1a\u7fa4\u9593\u5dee\uff08\u6a19\u6e96\u504f\u5dee\u3092\uff11\u3068\u3059\u308c\u3070\u52b9\u679c\u91cf\uff09<\/h2>\n\n\n\n<p>\u6700\u5f8c\u7fa4\u9593\u5dee\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u4e0a\u8a18\u306e\u9023\u7d9a\u5909\u6570\u306e\u8981\u7d04\u5024\u306e\u51fa\u529b\u304b\u3089\u624b\u8a08\u7b97\u3067\u3001\u5927\u4f5317\u304f\u3089\u3044\u3068\u63a8\u5b9a\u3067\u304d\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"578\" height=\"158\" src=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008212309.png\" alt=\"\" class=\"wp-image-1385\" title=\"\" srcset=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008212309.png 578w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008212309-300x82.png 300w\" sizes=\"(max-width: 578px) 100vw, 578px\" \/><\/figure>\n\n\n\n<p><span itemscope=\"\" itemtype=\"http:\/\/schema.org\/Photograph\"><\/span><\/p>\n\n\n\n<p>\u306a\u306e\u3067\u3001\u7fa4\u9593\u5dee\u306f17\u3068\u3059\u308b\u3002<\/p>\n\n\n\n<p>\u3042\u3068\u306f\u3001\u4e21\u5074\u691c\u5b9a\u3001\uff54\u691c\u5b9a\u3001\u03b1\uff08\u6709\u610f\u6c34\u6e96\uff090.05\u30011\uff0d\u03b2\uff08\u691c\u51fa\u529b\uff090.8\u3068\u306e\u30c7\u30d5\u30a9\u30eb\u30c8\u306e\u307e\u307e\u3001Submit\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"MMRM-\u306e\u5fc5\u8981\u306a\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\">MMRM \u306e\u5fc5\u8981\u306a\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba<\/h2>\n\n\n\n<p>\u53f3\u5074\u306b\u8a08\u7b97\u7d50\u679c\u304c\u51fa\u529b\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"562\" height=\"905\" src=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008212527.png\" alt=\"\" class=\"wp-image-1386\" title=\"\" srcset=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008212527.png 562w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008212527-186x300.png 186w\" sizes=\"(max-width: 562px) 100vw, 562px\" \/><\/figure>\n\n\n\n<p><span itemscope=\"\" itemtype=\"http:\/\/schema.org\/Photograph\"><\/span><\/p>\n\n\n\n<p>\u5408\u8a08\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c58\u3001A\u30fbB\u7fa4\u3068\u3082\u306b\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306f29\u3001\u3068\u8a08\u7b97\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u30b5\u30f3\u30d7\u30eb\u30c7\u30fc\u30bf\u306f40\u4f8b\u3067\u3042\u308b\u306e\u3067\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u4e0a\u306f1.5\u500d\u7a0b\u5ea6\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c\u5fc5\u8981\u3068\u306e\u3053\u3068\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u975e\u6b20\u6e2c\u306e\u5024\u3092\u5927\u304d\u304f\uff08\u3064\u307e\u308a\u6b20\u6e2c\u306e\u5272\u5408\u3092\u5c0f\u3055\u304f\uff09\u3059\u308b\u3068\u3001\u5fc5\u8981\u306a\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306f\u5c0f\u3055\u304f\u306a\u308b\u3002<\/p>\n\n\n\n<p>\u3084\u306f\u308a\u3001\u6b20\u6e2c\u306f\u306a\u308b\u3079\u304f\u5c11\u306a\u3044\u306e\u306b\u8d8a\u3057\u305f\u3053\u3068\u306f\u306a\u3044\u3088\u3046\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"MMRM-\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306e\u305f\u3081\u306e\u30b5\u30f3\u30d7\u30eb\u30c7\u30fc\u30bf\u306e\u8996\u899a\u5316\u89e3\u6790\u7d50\u679c\">MMRM \u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306e\u305f\u3081\u306e\u30b5\u30f3\u30d7\u30eb\u30c7\u30fc\u30bf\u306e\u8996\u899a\u5316\u30fb\u89e3\u6790\u7d50\u679c<\/h2>\n\n\n\n<p>\u3061\u306a\u307f\u306b\u30b5\u30f3\u30d7\u30eb\u3068\u3057\u3066\u4f7f\u3063\u3066\u3044\u308b\u30c7\u30fc\u30bf\u306e\u5e73\u5747\u5024\u30b0\u30e9\u30d5\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u306a\u308b\u3002<\/p>\n\n\n\n<p>\uff12\u3064\u306e\u7fa4\u304c\u304d\u3063\u3061\u308a\u96e2\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"672\" height=\"672\" src=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008213051.png\" alt=\"\" class=\"wp-image-1387\" title=\"\" srcset=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008213051.png 672w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008213051-300x300.png 300w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008213051-150x150.png 150w\" sizes=\"(max-width: 672px) 100vw, 672px\" \/><\/figure>\n\n\n\n<p><span itemscope=\"\" itemtype=\"http:\/\/schema.org\/Photograph\"><\/span><\/p>\n\n\n\n<p>\u7d71\u8a08\u89e3\u6790\u7d50\u679c\u3082\u3001\u7fa4\u306e\u52b9\u679c\u306f\u7d71\u8a08\u5b66\u7684\u6709\u610f\u3067\u3042\u308b\uff08\u30cf\u30a4\u30e9\u30a4\u30c8\u90e8\u5206\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"702\" height=\"153\" src=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008213158.png\" alt=\"\" class=\"wp-image-1388\" title=\"\" srcset=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008213158.png 702w, https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008213158-300x65.png 300w\" sizes=\"(max-width: 702px) 100vw, 702px\" \/><\/figure>\n\n\n\n<p><span itemscope=\"\" itemtype=\"http:\/\/schema.org\/Photograph\"><\/span><\/p>\n\n\n\n<p>\u306a\u306e\u3067\u3001\u30b5\u30f3\u30d7\u30ea\u30f3\u30b0\u3057\u305f\u30c7\u30fc\u30bf\u306b\u3088\u3063\u3066\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u304f\u3066\u3082\u7d71\u8a08\u5b66\u7684\u6709\u610f\u306b\u306a\u308a\u3046\u308b\u3002<\/p>\n\n\n\n<p>\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u3067\u304d\u308c\u3070\u4e8b\u524d\u306b\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u3092\u898b\u7a4d\u3082\u3063\u3066\u304b\u3089\u8a66\u9a13\u306a\u308a\u3001\u7814\u7a76\u30c7\u30fc\u30bf\u53ce\u96c6\u306a\u308a\u306b\u9032\u3093\u3060\u307b\u3046\u304c\u3001\u3042\u3068\u3042\u3068\u5b89\u5fc3\u3067\u304d\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u307e\u3068\u3081\">\u307e\u3068\u3081<\/h2>\n\n\n\n<p>MMRM\u3068\u547c\u3070\u308c\u308b\u53cd\u5fa9\u6e2c\u5b9a\u306e\u7dda\u5f62\u6df7\u5408\u30e2\u30c7\u30eb\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u30d7\u30ed\u30b0\u30e9\u30e0\u30b5\u30a4\u30c8\u306e\u4f7f\u3044\u65b9\u3092\u7d39\u4ecb\u3057\u305f\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/nshi.jp\/contents\/js\/mmrm\/\">MMRM\u306b\u5bfe\u3059\u308b\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a2d\u8a08 | Kengo Nagashima &#8211; Keio University<\/a><\/p>\n\n\n\n<p>\u3044\u308d\u3044\u308d\u3068\u524d\u63d0\u6761\u4ef6\u3092\u5165\u308c\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u5148\u884c\u7814\u7a76\u3084\u30d1\u30a4\u30ed\u30c3\u30c8\u7814\u7a76\u3092\u53c2\u8003\u306b\u3057\u3066\u306a\u308b\u3079\u304f\u78ba\u5b9f\u306a\u524d\u63d0\u6761\u4ef6\u3092\u5165\u308c\u305f\u3044\u3002<\/p>\n\n\n\n<p>\u53c2\u8003\u306b\u306a\u308c\u3070\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u8a08\u7b97\u30d7\u30ed\u30b0\u30e9\u30e0\u30b5\u30a4\u30c8\">\u8a08\u7b97\u30d7\u30ed\u30b0\u30e9\u30e0\u30b5\u30a4\u30c8<\/h2>\n\n\n\n<p><a href=\"https:\/\/nshi.jp\/contents\/js\/mmrm\/\">MMRM\u306b\u5bfe\u3059\u308b\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a2d\u8a08 | Kengo Nagashima &#8211; Keio University<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u304a\u3059\u3059\u3081\u66f8\u7c4d\">\u304a\u3059\u3059\u3081\u66f8\u7c4d<\/h2>\n\n\n\n<p>EZR\u516c\u5f0f\u30de\u30cb\u30e5\u30a2\u30eb<\/p>\n\n\n\n<div class=\"hatena-asin-detail\"><a href=\"https:\/\/www.amazon.co.jp\/dp\/449810918X?tag=ttyotani-22&amp;linkCode=ogi&amp;th=1&amp;psc=1\" class=\"hatena-asin-detail-image-link\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/m.media-amazon.com\/images\/I\/51ouXcnW2-L._SL500_.jpg\" class=\"hatena-asin-detail-image\" alt=\"EZR\u3067\u3084\u3055\u3057\u304f\u5b66\u3076\u7d71\u8a08\u5b66 \u6539\u8a023\u7248 \u301cEBM\u306e\u5b9f\u8df5\u304b\u3089\u81e8\u5e8a\u7814\u7a76\u307e\u3067\u301c\" title=\"EZR\u3067\u3084\u3055\u3057\u304f\u5b66\u3076\u7d71\u8a08\u5b66 \u6539\u8a023\u7248 \u301cEBM\u306e\u5b9f\u8df5\u304b\u3089\u81e8\u5e8a\u7814\u7a76\u307e\u3067\u301c\"><\/a>\n<div class=\"hatena-asin-detail-info\">\n<p class=\"hatena-asin-detail-title\"><a href=\"https:\/\/www.amazon.co.jp\/dp\/449810918X?tag=ttyotani-22&amp;linkCode=ogi&amp;th=1&amp;psc=1\" target=\"_blank\" rel=\"noopener\">EZR\u3067\u3084\u3055\u3057\u304f\u5b66\u3076\u7d71\u8a08\u5b66 \u6539\u8a023\u7248 \u301cEBM\u306e\u5b9f\u8df5\u304b\u3089\u81e8\u5e8a\u7814\u7a76\u307e\u3067\u301c<\/a><\/p>\n<ul class=\"hatena-asin-detail-meta\">\n<li><span class=\"hatena-asin-detail-label\">\u4f5c\u8005:<\/span><a href=\"https:\/\/d.hatena.ne.jp\/keyword\/%BF%C0%C5%C4%20%C1%B1%BF%AD\" class=\"keyword\">\u795e\u7530 \u5584\u4f38<\/a><\/li>\n<li>\u4e2d\u5916\u533b\u5b66\u793e<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.amazon.co.jp\/dp\/449810918X?tag=ttyotani-22&amp;linkCode=ogi&amp;th=1&amp;psc=1\" class=\"asin-detail-buy\" target=\"_blank\" rel=\"noopener\">Amazon<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>MMRM\u306f\u3001Mixed Model with Repeated Measures\u306e\u7565\u3067\u3042\u308b\u3002 \u53cd\u5fa9\u6e2c\u5b9a\u306e\u9023\u7d9a\u30c7\u30fc\u30bf\u3092\u7dda\u5f62\u6df7\u5408\u30e2\u30c7\u30eb\u3067\u89e3\u6790\u3059\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u3066\u3044\u308b\u3002 \u3053\u306e\u8a66\u9a13\u30fb\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u306e\u3068\u304d\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u306f\u3069\u306e\u3088\u3046 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":1387,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[16,59],"tags":[],"class_list":["post-239","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-16","category-59"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2022\/10\/20221008213051.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts\/239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/comments?post=239"}],"version-history":[{"count":1,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts\/239\/revisions"}],"predecessor-version":[{"id":1389,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts\/239\/revisions\/1389"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/media\/1387"}],"wp:attachment":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/media?parent=239"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/categories?post=239"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/tags?post=239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}