{"id":4038,"date":"2025-06-20T17:43:42","date_gmt":"2025-06-20T08:43:42","guid":{"rendered":"https:\/\/best-biostatistics.com\/toukei-er\/?p=4038"},"modified":"2025-06-20T17:43:45","modified_gmt":"2025-06-20T08:43:45","slug":"linear-mixed-effects-model-a-powerful-tool-for-repeated-measures-data-analysis","status":"publish","type":"post","link":"https:\/\/best-biostatistics.com\/toukei-er\/entry\/linear-mixed-effects-model-a-powerful-tool-for-repeated-measures-data-analysis\/","title":{"rendered":"\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\uff1a\u53cd\u5fa9\u6e2c\u5b9a\u30c7\u30fc\u30bf\u89e3\u6790\u306e\u5f37\u529b\u306a\u30c4\u30fc\u30eb"},"content":{"rendered":"\n<p>\u81e8\u5e8a\u7814\u7a76\u3084\u751f\u7269\u5b66\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u540c\u3058\u88ab\u9a13\u8005\u304b\u3089\u8907\u6570\u56de\u6e2c\u5b9a\u3055\u308c\u305f\u30c7\u30fc\u30bf\uff08\u53cd\u5fa9\u6e2c\u5b9a\u30c7\u30fc\u30bf\uff09\u306f\u983b\u7e41\u306b\u767b\u5834\u3059\u308b\u3002\u3053\u306e\u3088\u3046\u306a\u30c7\u30fc\u30bf\u306f\u3001\u5f93\u6765\u306e\u7dda\u5f62\u56de\u5e30\u30e2\u30c7\u30eb\u3067\u306f\u9069\u5207\u306b\u89e3\u6790\u3067\u304d\u306a\u3044\u5834\u5408\u304c\u3042\u308b\u3002\u306a\u305c\u306a\u3089\u3001\u540c\u3058\u88ab\u9a13\u8005\u304b\u3089\u306e\u6e2c\u5b9a\u5024\u306f\u4e92\u3044\u306b\u76f8\u95a2\u3092\u6301\u3064\u305f\u3081\u3001\u72ec\u7acb\u6027\u306e\u4eee\u5b9a\u304c\u6e80\u305f\u3055\u308c\u306a\u3044\u304b\u3089\u3002\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\uff08Linear Mixed-Effects Model; LMM\uff09\u306f\u3001\u3053\u306e\u3088\u3046\u306a\u53cd\u5fa9\u6e2c\u5b9a\u30c7\u30fc\u30bf\u3084\u968e\u5c64\u7684\u69cb\u9020\u3092\u6301\u3064\u30c7\u30fc\u30bf\u306e\u89e3\u6790\u306b\u7279\u5316\u3057\u305f\u7d71\u8a08\u30e2\u30c7\u30eb\u3067\u3042\u308a\u3001\u500b\u4f53\u9593\u306e\u3070\u3089\u3064\u304d\u3068\u500b\u4f53\u5185\u3067\u306e\u7d4c\u6642\u7684\u306a\u5909\u5316\u306e\u4e21\u65b9\u3092\u540c\u6642\u306b\u8003\u616e\u3067\u304d\u308b\u5f37\u529b\u306a\u30c4\u30fc\u30eb\u3067\u3042\u308b\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u306e\u57fa\u672c\u6982\u5ff5\u304b\u3089\u3001\u305d\u306e\u4eee\u5b9a\u3001\u81e8\u5e8a\u7814\u7a76\u3067\u306e\u5177\u4f53\u4f8b\u3001\u305d\u3057\u3066\u7d71\u8a08\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2R\u3092\u7528\u3044\u305f\u8a08\u7b97\u4f8b\u307e\u3067\u3092\u89e3\u8aac\u3002<\/p>\n\n\n\n<!--more-->\n\n\n\n<h2 class=\"wp-block-heading\">\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u306e\u6982\u8981<\/h2>\n\n\n\n<p>\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\uff08\u4ee5\u4e0b\u3001\u6df7\u5408\u30e2\u30c7\u30eb\u3068\u3082\u547c\u3076\uff09\u306f\u3001\u56fa\u5b9a\u52b9\u679c\uff08fixed effects\uff09\u3068\u5909\u91cf\u52b9\u679c\uff08random effects\uff09\u3068\u3044\u30462\u3064\u306e\u7570\u306a\u308b\u52b9\u679c\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u7dda\u5f62\u30e2\u30c7\u30eb\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u56fa\u5b9a\u52b9\u679c\uff08Fixed Effects\uff09<\/strong>: \u7814\u7a76\u8005\u304c\u95a2\u5fc3\u3092\u6301\u3064\u3001\u6bcd\u96c6\u56e3\u5168\u4f53\u306b\u308f\u305f\u3063\u3066\u56fa\u5b9a\u3055\u308c\u305f\u52b9\u679c\u306e\u3053\u3068\u3002\u4f8b\u3048\u3070\u3001\u85ac\u5264\u306e\u52b9\u679c\u3001\u6cbb\u7642\u7fa4\u3068\u5bfe\u7167\u7fa4\u306e\u5dee\u3001\u6027\u5225\u306e\u5f71\u97ff\u306a\u3069\u304c\u3053\u308c\u306b\u3042\u305f\u308b\u3002\u5f93\u6765\u306e\u7dda\u5f62\u56de\u5e30\u30e2\u30c7\u30eb\u3067\u6271\u308f\u308c\u308b\u8aac\u660e\u5909\u6570\u3068\u540c\u69d8\u306e\u3082\u306e\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5909\u91cf\u52b9\u679c\uff08Random Effects\uff09<\/strong>: \u500b\u3005\u306e\u88ab\u9a13\u8005\u3084\u30b0\u30eb\u30fc\u30d7\u9593\u3067\u7570\u306a\u308b\u3070\u3089\u3064\u304d\u3092\u8868\u73fe\u3059\u308b\u52b9\u679c\u306e\u3053\u3068\u3002\u4f8b\u3048\u3070\u3001\u88ab\u9a13\u8005\u3054\u3068\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5024\u306e\u9055\u3044\u3001\u88ab\u9a13\u8005\u3054\u3068\u306e\u85ac\u5264\u3078\u306e\u53cd\u5fdc\u6027\u306e\u9055\u3044\u306a\u3069\u304c\u3053\u308c\u306b\u3042\u305f\u308b\u3002\u3053\u308c\u3089\u306e\u52b9\u679c\u306f\u3001\u7279\u5b9a\u306e\u88ab\u9a13\u8005\u3084\u30b0\u30eb\u30fc\u30d7\u306b\u56fa\u6709\u306e\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u3088\u308a\u5927\u304d\u306a\u6bcd\u96c6\u56e3\u304b\u3089\u30e9\u30f3\u30c0\u30e0\u306b\u62bd\u51fa\u3055\u308c\u305f\u3082\u306e\u3068\u898b\u306a\u3055\u308c\u308b\u3002\u5909\u91cf\u52b9\u679c\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u3001\u500b\u4f53\u5185\u306e\u6e2c\u5b9a\u5024\u9593\u306e\u76f8\u95a2\u3092\u30e2\u30c7\u30eb\u306b\u7d44\u307f\u8fbc\u3080\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u306e\u57fa\u672c\u7684\u306a\u5f62\u5f0f\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u8868\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>$$ Y = X \\beta + Z \\gamma + \\varepsilon $$<\/p>\n\n\n\n<p>\u3053\u3053\u3067\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Y \u306f\u5fdc\u7b54\u5909\u6570\uff08\u76ee\u7684\u5909\u6570\uff09\u306e\u30d9\u30af\u30c8\u30eb<\/li>\n\n\n\n<li>X \u306f\u56fa\u5b9a\u52b9\u679c\u306e\u8a08\u753b\u884c\u5217<\/li>\n\n\n\n<li>\u03b2 \u306f\u56fa\u5b9a\u52b9\u679c\u306e\u4fc2\u6570\u30d9\u30af\u30c8\u30eb<\/li>\n\n\n\n<li>Z \u306f\u5909\u91cf\u52b9\u679c\u306e\u8a08\u753b\u884c\u5217<\/li>\n\n\n\n<li>\u03b3 \u306f\u5909\u91cf\u52b9\u679c\u306e\u4fc2\u6570\u30d9\u30af\u30c8\u30eb\uff08\u78ba\u7387\u5909\u6570\uff09<\/li>\n\n\n\n<li>\u03f5 \u306f\u6b8b\u5dee\u8aa4\u5dee\u30d9\u30af\u30c8\u30eb<\/li>\n<\/ul>\n\n\n\n<p>\u3067\u3042\u308b\u3002\u03b3 \u3068 \u03f5 \u306f\u3001\u305d\u308c\u305e\u308c\u7279\u5b9a\u306e\u5206\u5e03\uff08\u901a\u5e38\u306f\u6b63\u898f\u5206\u5e03\uff09\u306b\u5f93\u3046\u3068\u4eee\u5b9a\u3059\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6df7\u5408\u30e2\u30c7\u30eb\u306e\u8a08\u753b\u884c\u5217\u3068\u306f<\/h2>\n\n\n\n<p>\u8a08\u753b\u884c\u5217\uff08Design Matrix\uff09\u306f\u3001\u7d71\u8a08\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u8aac\u660e\u5909\u6570\u3068\u30e2\u30c7\u30eb\u306e\u4fc2\u6570\u306e\u95a2\u4fc2\u3092\u8868\u73fe\u3059\u308b\u305f\u3081\u306b\u7528\u3044\u3089\u308c\u308b\u884c\u5217\u306e\u3053\u3068\u3067\u3042\u308b\u3002\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u306f\u3001\u56fa\u5b9a\u52b9\u679c\u3068\u5909\u91cf\u52b9\u679c\u305d\u308c\u305e\u308c\u306b\u5bfe\u3057\u3066\u8a08\u753b\u884c\u5217\u304c\u5b58\u5728\u3059\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u56fa\u5b9a\u52b9\u679c\u306e\u8a08\u753b\u884c\u5217 (X)<\/strong>: \u56fa\u5b9a\u52b9\u679c\u306e\u8a08\u753b\u884c\u5217\u306f\u3001\u5f93\u6765\u306e\u7dda\u5f62\u56de\u5e30\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u8a08\u753b\u884c\u5217\u3068\u540c\u69d8\u306e\u5f79\u5272\u3092\u679c\u305f\u3059\u3002\u5404\u884c\u304c\u500b\u3005\u306e\u89b3\u6e2c\u5024\u3092\u8868\u3057\u3001\u5404\u5217\u304c\u56fa\u5b9a\u52b9\u679c\u306e\u8aac\u660e\u5909\u6570\uff08\u4f8b\uff1a\u4ecb\u5165\u7fa4\u304b\u5bfe\u7167\u7fa4\u304b\u3001\u6027\u5225\u3001\u6642\u9593\u306a\u3069\uff09\u306b\u5bfe\u5fdc\u3059\u308b\u3002\u4f8b\u3048\u3070\u3001\u5207\u7247\u3001\u6642\u9593\u3001\u4ecb\u5165\u7fa4\u306a\u3069\u306e\u56fa\u5b9a\u52b9\u679c\u304c\u3042\u308b\u5834\u5408\u3001\u3053\u308c\u3089\u306e\u5909\u6570\u306e\u5024\u304c\u3053\u306e\u884c\u5217\u306b\u914d\u7f6e\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5909\u91cf\u52b9\u679c\u306e\u8a08\u753b\u884c\u5217 (Z)<\/strong>: \u5909\u91cf\u52b9\u679c\u306e\u8a08\u753b\u884c\u5217\u306f\u3001\u500b\u3005\u306e\u88ab\u9a13\u8005\u3084\u30b0\u30eb\u30fc\u30d7\u3054\u3068\u306b\u7570\u306a\u308b\u5909\u91cf\u52b9\u679c\u306e\u69cb\u9020\u3092\u5b9a\u7fa9\u3057\u3066\u3044\u308b\u3002\u4f8b\u3048\u3070\u3001\u5404\u88ab\u9a13\u8005\u306b\u5bfe\u3057\u3066\u7570\u306a\u308b\u5207\u7247\u3092\u6301\u3064\u30e2\u30c7\u30eb\u306e\u5834\u5408\u3001Z\u306f\u5404\u88ab\u9a13\u8005\u306e\u89b3\u6e2c\u5024\u304c\u3069\u306e\u88ab\u9a13\u8005\u306b\u5c5e\u3059\u308b\u304b\u3092\u793a\u3059\u3088\u3046\u306a\u69cb\u9020\u306b\u306a\u308b\u3002\u307e\u305f\u3001\u6642\u9593\u7d4c\u904e\u306b\u4f34\u3046\u5909\u5316\u304c\u88ab\u9a13\u8005\u3054\u3068\u306b\u7570\u306a\u308b\u5834\u5408\uff08\u5909\u91cf\u52fe\u914d\uff09\u3001Z\u306f\u6642\u9593\u5909\u6570\u3092\u88ab\u9a13\u8005\u3054\u3068\u306b\u7d10\u3065\u3051\u308b\u3088\u3046\u306a\u69cb\u9020\u3092\u6301\u3064\u3053\u3068\u306b\u306a\u308b\u3002Z\u884c\u5217\u306e\u69cb\u9020\u306f\u3001\u30e2\u30c7\u30eb\u3067\u3069\u306e\u3088\u3046\u306a\u5909\u91cf\u52b9\u679c\u3092\u8003\u616e\u3059\u308b\u304b\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u8a08\u753b\u884c\u5217\u306f\u3001\u30e2\u30c7\u30eb\u306e\u4eee\u5b9a\u3084\u89e3\u6790\u306e\u76ee\u7684\u306b\u5fdc\u3058\u3066\u67d4\u8edf\u306b\u8a2d\u5b9a\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<div id=\"biost-3668914538\" class=\"biost- biost-entity-placement\"><p style=\"text-align: center;\"><span style=\"font-size: 20px;\"><strong><a href=\"https:\/\/best-biostatistics.com\/kmhl\">\uff1e\uff1e\u3082\u3046\u7d71\u8a08\u3067\u60a9\u3080\u306e\u306f\u7d42\u308f\u308a\u306b\u3057\u307e\u305b\u3093\u304b\uff1f\u00a0<\/a><\/strong><\/span><\/p>\r\n<a href=\"https:\/\/best-biostatistics.com\/kmhl\"><img class=\"aligncenter wp-image-2794 size-full\" src=\"https:\/\/best-biostatistics.com\/wp\/wp-content\/uploads\/2023\/11\/bn_r_03.png\" alt=\"\" width=\"500\" height=\"327\" \/><\/a>\r\n<p style=\"text-align: center;\"><span style=\"color: #ff0000; font-size: 20px;\"><strong><span class=\"marker2\">\u21911\u4e07\u4eba\u4ee5\u4e0a\u306e\u533b\u7642\u5f93\u4e8b\u8005\u304c\u8cfc\u8aad\u4e2d<\/span><\/strong><\/span><\/p><\/div><h2 class=\"wp-block-heading\">\u6df7\u5408\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u30e2\u30c7\u30eb\u306e\u4eee\u5b9a<\/h2>\n\n\n\n<p>\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u306b\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u91cd\u8981\u306a\u4eee\u5b9a\u304c\u3042\u308b\u3002\u3053\u308c\u3089\u306f\u3001\u30e2\u30c7\u30eb\u306e\u63a8\u5b9a\u7d50\u679c\u306e\u59a5\u5f53\u6027\u3084\u4fe1\u983c\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3046\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7dda\u5f62\u6027<\/strong>: \u5fdc\u7b54\u5909\u6570\u3068\u56fa\u5b9a\u52b9\u679c\u304a\u3088\u3073\u5909\u91cf\u52b9\u679c\u3068\u306e\u95a2\u4fc2\u304c\u7dda\u5f62\u3067\u3042\u308b\u3053\u3068\u3002<\/li>\n\n\n\n<li><strong>\u6b8b\u5dee\u306e\u6b63\u898f\u6027<\/strong>: \u6b8b\u5dee\u8aa4\u5dee \u03f5 \u304c\u5e73\u57470\u306e\u6b63\u898f\u5206\u5e03\u306b\u5f93\u3046\u3053\u3068\u3002<\/li>\n\n\n\n<li><strong>\u5909\u91cf\u52b9\u679c\u306e\u6b63\u898f\u6027<\/strong>: \u5909\u91cf\u52b9\u679c \u03b3 \u304c\u5e73\u57470\u306e\u6b63\u898f\u5206\u5e03\u306b\u5f93\u3046\u3053\u3068\u3002<\/li>\n\n\n\n<li><strong>\u5909\u91cf\u52b9\u679c\u3068\u6b8b\u5dee\u306e\u72ec\u7acb\u6027<\/strong>: \u5909\u91cf\u52b9\u679c\u3068\u6b8b\u5dee\u8aa4\u5dee\u304c\u4e92\u3044\u306b\u72ec\u7acb\u3067\u3042\u308b\u3053\u3068\u3002<\/li>\n\n\n\n<li><strong>\u5747\u4e00\u5206\u6563<\/strong>: \u6b8b\u5dee\u306e\u5206\u6563\u304c\u5747\u4e00\u3067\u3042\u308b\u3053\u3068\u3002<\/li>\n\n\n\n<li><strong>\u5171\u5206\u6563\u69cb\u9020<\/strong>: \u5909\u91cf\u52b9\u679c\u306b\u3088\u3063\u3066\u6355\u6349\u3055\u308c\u306a\u3044\u6b8b\u5dee\u306e\u5171\u5206\u6563\u69cb\u9020\u306b\u95a2\u3059\u308b\u4eee\u5b9a\uff08\u4f8b\u3048\u3070\u3001\u89b3\u6e2c\u5024\u9593\u306e\u72ec\u7acb\u6027\u3084\u3001\u6642\u9593\u7d4c\u904e\u306b\u4f34\u3046\u76f8\u95a2\u306e\u6e1b\u8870\u306a\u3069\uff09\u3002\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u306f\u3001\u5909\u91cf\u52b9\u679c\u3092\u901a\u3058\u3066\u500b\u4f53\u5185\u306e\u6e2c\u5b9a\u5024\u9593\u306e\u76f8\u95a2\u3092\u30e2\u30c7\u30eb\u5316\u3059\u308b\u305f\u3081\u3001\u6b8b\u5dee\u306f\u6761\u4ef6\u4ed8\u304d\u3067\u72ec\u7acb\u3067\u3042\u308b\u3068\u4eee\u5b9a\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u4eee\u5b9a\u306f\u3001\u8a3a\u65ad\u30d7\u30ed\u30c3\u30c8\u3084\u7d71\u8a08\u7684\u691c\u5b9a\u3092\u7528\u3044\u3066\u78ba\u8a8d\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u81e8\u5e8a\u7814\u7a76\u306e\u5177\u4f53\u4f8b<\/h2>\n\n\n\n<p>\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u306f\u3001\u69d8\u3005\u306a\u81e8\u5e8a\u7814\u7a76\u3067\u305d\u306e\u6709\u7528\u6027\u3092\u767a\u63ee\u3059\u308b\u3002<\/p>\n\n\n\n<p><strong>\u4f8b\uff1a\u65b0\u3057\u3044\u964d\u5727\u5264\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u7814\u7a76<\/strong><\/p>\n\n\n\n<p>\u3042\u308b\u65b0\u3057\u3044\u964d\u5727\u5264\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u3001\u60a3\u8005\u3092\u4ecb\u5165\u7fa4\u3068\u5bfe\u7167\u7fa4\u306b\u5206\u3051\u3001\u305d\u308c\u305e\u308c6\u30f6\u6708\u9593\u3001\u6bce\u6708\u8840\u5727\u3092\u6e2c\u5b9a\u3059\u308b\u7814\u7a76\u3092\u8a08\u753b\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u76ee\u7684<\/strong>: \u65b0\u3057\u3044\u964d\u5727\u5264\u304c\u8840\u5727\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u52b9\u679c\u304c\u3042\u308b\u304b\u3001\u307e\u305f\u305d\u306e\u52b9\u679c\u304c\u6642\u9593\u7d4c\u904e\u3068\u3068\u3082\u306b\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3059\u308b\u304b\u3092\u8a55\u4fa1\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u53cd\u5fa9\u6e2c\u5b9a\u30c7\u30fc\u30bf<\/strong>: \u5404\u60a3\u8005\u306f\u6bce\u6708\u8840\u5727\u304c\u6e2c\u5b9a\u3055\u308c\u308b\u305f\u3081\u3001\u53cd\u5fa9\u6e2c\u5b9a\u30c7\u30fc\u30bf\u306b\u306a\u308b\u3002<\/li>\n\n\n\n<li><strong>\u554f\u984c\u70b9<\/strong>:\n<ul class=\"wp-block-list\">\n<li>\u540c\u3058\u60a3\u8005\u306e\u8840\u5727\u6e2c\u5b9a\u5024\u306f\u3001\u4ed6\u306e\u60a3\u8005\u306e\u6e2c\u5b9a\u5024\u3068\u6bd4\u8f03\u3057\u305f\u3068\u304d\u306e\u3088\u3046\u306a\u3001\u72ec\u7acb\u306a\u72b6\u614b\u3067\u306f\u306a\u3044\uff08\u60a3\u8005\u56fa\u6709\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u8840\u5727\u3084\u85ac\u5264\u3078\u306e\u53cd\u5fdc\u6027\u304c\u3042\u308b\u305f\u3081\uff09\u3002<\/li>\n\n\n\n<li>\u60a3\u8005\u306b\u3088\u3063\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u8840\u5727\u304c\u7570\u306a\u308b\u3002<\/li>\n\n\n\n<li>\u85ac\u5264\u306e\u52b9\u679c\u304c\u60a3\u8005\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u306e\u9069\u7528<\/strong>:<\/p>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u9069\u7528\u3067\u304d\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5fdc\u7b54\u5909\u6570<\/strong>: \u8840\u5727\u306e\u5024<\/li>\n\n\n\n<li><strong>\u56fa\u5b9a\u52b9\u679c<\/strong>:\n<ul class=\"wp-block-list\">\n<li><strong>\u6642\u9593<\/strong>: \u6cbb\u7642\u958b\u59cb\u304b\u3089\u306e\u6708\u6570\uff08\u4f8b\uff1a0, 1, 2, &#8230;, 6\uff09<\/li>\n\n\n\n<li><strong>\u4ecb\u5165\u7fa4\/\u5bfe\u7167\u7fa4<\/strong>: \u60a3\u8005\u304c\u3069\u3061\u3089\u306e\u7fa4\u306b\u5c5e\u3059\u308b\u304b\u3092\u793a\u3059\u30c0\u30df\u30fc\u5909\u6570<\/li>\n\n\n\n<li><strong>\u6642\u9593\u3068\u7fa4\u306e\u4ea4\u4e92\u4f5c\u7528<\/strong>: \u85ac\u5264\u306e\u52b9\u679c\u304c\u6642\u9593\u7d4c\u904e\u3068\u3068\u3082\u306b\u7570\u306a\u308b\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\uff08\u4f8b\uff1a\u6642\u9593 \u00d7 \u4ecb\u5165\u7fa4\uff09<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u5909\u91cf\u52b9\u679c<\/strong>:\n<ul class=\"wp-block-list\">\n<li><strong>\u60a3\u8005\u3054\u3068\u306e\u5207\u7247<\/strong>: \u60a3\u8005\u3054\u3068\u306b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u8840\u5727\u304c\u7570\u306a\u308b\u3053\u3068\u3092\u8003\u616e\u3059\u308b\uff08\u4f8b\uff1a\u5404\u60a3\u8005\u306b\u56fa\u6709\u306e\u30e9\u30f3\u30c0\u30e0\u5207\u7247\uff09<\/li>\n\n\n\n<li><strong>(\u542b\u3081\u308b\u3053\u3068\u3082\u3042\u308b) \u60a3\u8005\u3054\u3068\u306e\u6642\u9593\u306e\u50be\u304d<\/strong>: \u85ac\u5264\u3078\u306e\u53cd\u5fdc\u6027\u304c\u60a3\u8005\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3053\u3068\u3092\u8003\u616e\u3059\u308b\uff08\u4f8b\uff1a\u5404\u60a3\u8005\u306b\u56fa\u6709\u306e\u30e9\u30f3\u30c0\u30e0\u52fe\u914d\uff09<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u30e2\u30c7\u30eb\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u4ee5\u4e0b\u306e\u3053\u3068\u3092\u540c\u6642\u306b\u8a55\u4fa1\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u85ac\u5264\u306e\u5168\u4f53\u7684\u306a\u52b9\u679c\uff08\u56fa\u5b9a\u52b9\u679c\uff09\u3002<\/li>\n\n\n\n<li>\u6642\u9593\u7d4c\u904e\u306b\u4f34\u3046\u8840\u5727\u306e\u5909\u5316\uff08\u56fa\u5b9a\u52b9\u679c\uff09\u3002<\/li>\n\n\n\n<li>\u60a3\u8005\u9593\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u8840\u5727\u306e\u3070\u3089\u3064\u304d\uff08\u5909\u91cf\u52b9\u679c\uff09\u3002<\/li>\n\n\n\n<li>\u60a3\u8005\u9593\u306e\u85ac\u5264\u53cd\u5fdc\u6027\u306e\u3070\u3089\u3064\u304d\uff08\u5909\u91cf\u52b9\u679c\u3001\u3082\u3057\u542b\u3081\u308b\u5834\u5408\uff09\u3002<\/li>\n\n\n\n<li>\u500b\u3005\u306e\u60a3\u8005\u5185\u3067\u306e\u8840\u5727\u306e\u7d4c\u6642\u7684\u5909\u5316\u306e\u30d1\u30bf\u30fc\u30f3\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u5f93\u6765\u306eANOVA\u3084\u7e70\u308a\u8fd4\u3057\u6e2c\u5b9aANOVA\uff08\u53cd\u5fa9\u6e2c\u5b9a\u5206\u6563\u5206\u6790\uff09\u3067\u306f\u3001\u500b\u4f53\u9593\u306e\u3070\u3089\u3064\u304d\u3068\u500b\u4f53\u5185\u3067\u306e\u7d4c\u6642\u7684\u306a\u5909\u5316\u3092\u3053\u3053\u307e\u3067\u67d4\u8edf\u306b\u30e2\u30c7\u30eb\u5316\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3042\u308b\u3002\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u73fe\u5b9f\u306b\u5373\u3057\u305f\u30c7\u30fc\u30bf\u89e3\u6790\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u4ecb\u5165\u306e\u771f\u306e\u52b9\u679c\u3092\u3088\u308a\u6b63\u78ba\u306b\u63a8\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">R\u306b\u3088\u308b\u8a08\u7b97\u4f8b<\/h2>\n\n\n\n<p>\u3053\u3053\u3067\u306f\u3001R\u306e<code>lme4<\/code>\u30d1\u30c3\u30b1\u30fc\u30b8\u3068<code>lmerTest<\/code>\u30d1\u30c3\u30b1\u30fc\u30b8\u3092\u7528\u3044\u305f\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u306e\u7c21\u5358\u306a\u8a08\u7b97\u4f8b\u3092\u793a\u3059\u3002\u67b6\u7a7a\u306e\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u3092\u4f5c\u6210\u3057\u3001\u524d\u8ff0\u306e\u964d\u5727\u5264\u306e\u7814\u7a76\u306b\u4f3c\u305f\u72b6\u6cc1\u306e\u89e3\u6790\u7d50\u679c\u3092\u793a\u3059\u3002<\/p>\n\n\n\n<pre class=\"wp-block-code\"><code># \u5fc5\u8981\u306a\u30d1\u30c3\u30b1\u30fc\u30b8\u306e\u30a4\u30f3\u30b9\u30c8\u30fc\u30eb (\u521d\u56de\u306e\u307f)\n# install.packages(\"lme4\")\n# install.packages(\"lmerTest\")\n# install.packages(\"ggplot2\") # \u7d50\u679c\u306e\u53ef\u8996\u5316\u7528\n\n# \u30d1\u30c3\u30b1\u30fc\u30b8\u306e\u8aad\u307f\u8fbc\u307f\nlibrary(lme4)\nlibrary(lmerTest) # lmer\u30e2\u30c7\u30eb\u306eP\u5024\u3092\u5f97\u308b\u305f\u3081\nlibrary(ggplot2)\n\n# \u67b6\u7a7a\u306e\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u306e\u4f5c\u6210\nset.seed(123)\nn_patients &lt;- 50 # \u60a3\u8005\u6570\nn_visits &lt;- 7    # \u6e2c\u5b9a\u56de\u6570 (\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3 + 6\u30f6\u6708)\n\n# \u60a3\u8005ID\u3068\u30b0\u30eb\u30fc\u30d7\u306e\u4f5c\u6210\npatient_id &lt;- factor(rep(1:n_patients, each = n_visits))\ngroup &lt;- factor(rep(c(\"Control\", \"Intervention\"), each = n_patients \/ 2 * n_visits))\n\n# \u6642\u9593\u5909\u6570\u306e\u4f5c\u6210 (0\u304b\u30896\u30f6\u6708)\ntime &lt;- rep(0:6, n_patients)\n\n# \u60a3\u8005\u3054\u3068\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u8840\u5727\u306e\u3070\u3089\u3064\u304d (\u5909\u91cf\u5207\u7247)\nrandom_intercepts &lt;- rnorm(n_patients, mean = 0, sd = 5)\npatient_baseline &lt;- rep(random_intercepts, each = n_visits)\n\n# \u56fa\u5b9a\u52b9\u679c: \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u8840\u5727, \u6642\u9593\u306e\u52b9\u679c, \u4ecb\u5165\u7fa4\u306e\u52b9\u679c, \u6642\u9593\u3068\u4ecb\u5165\u7fa4\u306e\u4ea4\u4e92\u4f5c\u7528\n# \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5e73\u5747\u8840\u5727\u3092130\u3068\u3059\u308b\nbaseline_bp &lt;- 130\ntime_effect &lt;- -1.5 # \u6642\u9593\u7d4c\u904e\u3067\u8840\u5727\u304c\u5c11\u3057\u4e0b\u304c\u308b\nintervention_effect &lt;- -5 # \u4ecb\u5165\u7fa4\u306f\u5bfe\u7167\u7fa4\u3088\u308a\u8840\u5727\u304c\u4f4e\u3044\ninteraction_effect &lt;- -1 # \u4ecb\u5165\u7fa4\u306f\u6642\u9593\u7d4c\u904e\u3068\u3068\u3082\u306b\u3055\u3089\u306b\u8840\u5727\u304c\u4e0b\u304c\u308b\n\n# \u8aa4\u5dee\nerror &lt;- rnorm(n_patients * n_visits, mean = 0, sd = 3)\n\n# \u8840\u5727\u306e\u8a08\u7b97\nblood_pressure &lt;- baseline_bp + patient_baseline +\n                  time * time_effect +\n                  ifelse(group == \"Intervention\", intervention_effect, 0) +\n                  ifelse(group == \"Intervention\", time * interaction_effect, 0) +\n                  error\n\n# \u30c7\u30fc\u30bf\u30d5\u30ec\u30fc\u30e0\u306e\u4f5c\u6210\ndata_bp &lt;- data.frame(\n  patient_id = patient_id,\n  group = group,\n  time = time,\n  blood_pressure = round(blood_pressure)\n)\n\n# \u30c7\u30fc\u30bf\u306e\u78ba\u8a8d (\u4e00\u90e8)\nhead(data_bp)\nsummary(data_bp)\n\n# \u6642\u7cfb\u5217\u30c7\u30fc\u30bf\u306e\u30d7\u30ed\u30c3\u30c8 (\u4e00\u90e8\u306e\u60a3\u8005\u306e\u307f)\nggplot(subset(data_bp, patient_id %in% c(1:10)), aes(x = time, y = blood_pressure, color = group, group = patient_id)) +\n  geom_line() +\n  geom_point() +\n  facet_wrap(~ patient_id) +\n  labs(title = \"Patients' Blood Pressure Over Time\", x = \"Time (Months)\", y = \"Blood Pressure\") +\n  theme_minimal()\n\n# \u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u306e\u30d5\u30a3\u30c3\u30c8\n# blood_pressure ~ time * group: \u6642\u9593\u3001\u30b0\u30eb\u30fc\u30d7\u3001\u6642\u9593\u3068\u30b0\u30eb\u30fc\u30d7\u306e\u4ea4\u4e92\u4f5c\u7528\u3092\u56fa\u5b9a\u52b9\u679c\u3068\u3059\u308b\n# (1 | patient_id): \u60a3\u8005\u3054\u3068\u306e\u5207\u7247\u3092\u5909\u91cf\u52b9\u679c\u3068\u3059\u308b (\u5404\u60a3\u8005\u306b\u56fa\u6709\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3)\nmodel_lmer &lt;- lmer(blood_pressure ~ time * group + (1 | patient_id), data = data_bp)\n\n# \u30e2\u30c7\u30eb\u306e\u8981\u7d04\nsummary(model_lmer)\n\n# \u5909\u91cf\u52fe\u914d\u3082\u8003\u616e\u3059\u308b\u5834\u5408 (\u5404\u60a3\u8005\u3067\u6642\u9593\u7d4c\u904e\u306b\u4f34\u3046\u8840\u5727\u5909\u5316\u306e\u50be\u304d\u304c\u7570\u306a\u308b)\n# (time | patient_id): \u60a3\u8005\u3054\u3068\u306e\u5207\u7247\u3068\u6642\u9593\u306b\u5bfe\u3059\u308b\u50be\u304d\u306e\u4e21\u65b9\u3092\u5909\u91cf\u52b9\u679c\u3068\u3059\u308b\n# model_lmer_rand_slope &lt;- lmer(blood_pressure ~ time * group + (time | patient_id), data = data_bp)\n# summary(model_lmer_rand_slope)<\/code><\/pre>\n\n\n\n<p><strong>\u5b9f\u884c\u7d50\u679c\uff1a<\/strong><\/p>\n\n\n\n<pre class=\"wp-block-code\"><code>&gt; # \u30e2\u30c7\u30eb\u306e\u8981\u7d04\n&gt; summary(model_lmer)\nLinear mixed model fit by REML. t-tests use Satterthwaite's method &#91;\nlmerModLmerTest]\nFormula: blood_pressure ~ time * group + (1 | patient_id)\n   Data: data_bp\n\nREML criterion at convergence: 1907.6\n\nScaled residuals: \n     Min       1Q   Median       3Q      Max \n-2.41813 -0.60511 -0.06565  0.60798  3.10148 \n\nRandom effects:\n Groups     Name        Variance Std.Dev.\n patient_id (Intercept) 23.886   4.887   \n Residual                8.978   2.996   \nNumber of obs: 350, groups:  patient_id, 50\n\nFixed effects:\n                       Estimate Std. Error       df t value Pr(&gt;|t|)    \n(Intercept)            129.4900     1.0593  59.5124 122.239  &lt; 2e-16 ***\ntime                    -1.3786     0.1133 298.0000 -12.173  &lt; 2e-16 ***\ngroupIntervention       -4.3671     1.4981  59.5124  -2.915    0.005 ** \ntime:groupIntervention  -0.9557     0.1602 298.0000  -5.967 6.84e-09 ***\n---\nSignif. codes:  0 \u2018***\u2019 0.001 \u2018**\u2019 0.01 \u2018*\u2019 0.05 \u2018.\u2019 0.1 \u2018 \u2019 1\n\nCorrelation of Fixed Effects:\n            (Intr) time   grpInt\ntime        -0.321              \ngrpIntrvntn -0.707  0.227       \ntm:grpIntrv  0.227 -0.707 -0.321\n&gt; <\/code><\/pre>\n\n\n\n<p><strong>\u51fa\u529b <strong>summary(model_lmer) <\/strong>\u306e\u89e3\u91c8<\/strong><\/p>\n\n\n\n<p><code>summary(model_lmer)<\/code>\u306e\u51fa\u529b\u306e Fixed effects \u306b\u7740\u76ee\u3059\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Fixed effects<\/strong>:<\/li>\n\n\n\n<li><code>Estimate<\/code>: \u5404\u56fa\u5b9a\u52b9\u679c\u306e\u63a8\u5b9a\u5024\u3002\u4f8b\u3048\u3070\u3001<code>time<\/code> \u306e\u63a8\u5b9a\u5024\u306f\u30011\u30f6\u6708\u3042\u305f\u308a\u306e\u8840\u5727\u5909\u5316\u3092\u793a\u3057\u3066\u3044\u308b\u3002<code>groupIntervention<\/code> \u306e\u63a8\u5b9a\u5024\u306f\u3001\u4ecb\u5165\u7fa4\u3068\u5bfe\u7167\u7fa4\u306e\u8840\u5727\u306e\u5dee\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><code>time:groupIntervention<\/code> \u306e\u63a8\u5b9a\u5024\u306f\u3001\u4ecb\u5165\u7fa4\u306b\u304a\u3051\u308b\u6642\u9593\u7d4c\u904e\u306b\u4f34\u3046\u8840\u5727\u5909\u5316\u306e\u52fe\u914d\u304c\u5bfe\u7167\u7fa4\u3068\u6bd4\u3079\u3066\u3069\u308c\u3060\u3051\u7570\u306a\u308b\u304b\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li><code>Std. Error<\/code>: \u6a19\u6e96\u8aa4\u5dee\u3002<\/li>\n\n\n\n<li><code>df<\/code>: \u81ea\u7531\u5ea6\u3002<\/li>\n\n\n\n<li><code>t value<\/code>: t\u5024\u3002<\/li>\n\n\n\n<li><code>Pr(&gt;|t|)<\/code>: P\u5024\u3002\u5404\u56fa\u5b9a\u52b9\u679c\u304c\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u3042\u308b\u304b\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u306e\u51fa\u529b\u3092\u898b\u308b\u3053\u3068\u3067\u3001\u964d\u5727\u5264\u304c\u8840\u5727\u306b\u53ca\u307c\u3059\u5f71\u97ff\uff08<code>groupIntervention<\/code>\uff09\u3084\u3001\u305d\u306e\u52b9\u679c\u304c\u6642\u9593\u3068\u3068\u3082\u306b\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3059\u308b\u304b\uff08<code>time:groupIntervention<\/code>\uff09\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/p>\n\n\n\n<p>\u4eca\u56de\u306e\u30c7\u30fc\u30bf\u3067\u306f\u3001\u4ea4\u4e92\u4f5c\u7528\u304c\u6709\u610f\u3067\u3042\u308b\u305f\u3081\u3001\u6642\u70b9\u3054\u3068\u306e\u6bd4\u8f03\u3092 EM \u5e73\u5747\u3092\u7528\u3044\u3066\u691c\u8a0e\u3059\u308b\u306e\u304c\u3088\u3044\u3002EM \u5e73\u5747\u3092\u7528\u3044\u308b\u691c\u8a0e\u306f\u5225\u8a18\u4e8b\u3067\u7d39\u4ecb\u3059\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u307e\u3068\u3081<\/h2>\n\n\n\n<p>\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u306f\u3001\u53cd\u5fa9\u6e2c\u5b9a\u30c7\u30fc\u30bf\u3084\u968e\u5c64\u7684\u69cb\u9020\u3092\u6301\u3064\u30c7\u30fc\u30bf\u306e\u89e3\u6790\u306b\u304a\u3044\u3066\u3001\u305d\u306e\u8907\u96d1\u306a\u69cb\u9020\u3092\u9069\u5207\u306b\u30e2\u30c7\u30eb\u5316\u3067\u304d\u308b\u975e\u5e38\u306b\u5f37\u529b\u306a\u7d71\u8a08\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3042\u308b\u3002\u56fa\u5b9a\u52b9\u679c\u3068\u5909\u91cf\u52b9\u679c\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u7814\u7a76\u8005\u304c\u95a2\u5fc3\u306e\u3042\u308b\u6bcd\u96c6\u56e3\u5168\u4f53\u306e\u52b9\u679c\u3068\u3001\u500b\u4f53\u9593\u306e\u3070\u3089\u3064\u304d\u306e\u4e21\u65b9\u3092\u540c\u6642\u306b\u8003\u616e\u3057\u3001\u3088\u308a\u7cbe\u5ea6\u306e\u9ad8\u3044\u63a8\u5b9a\u3068\u63a8\u8ad6\u3092\u53ef\u80fd\u306b\u3059\u308b\u3002\u81e8\u5e8a\u7814\u7a76\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u69d8\u3005\u306a\u5206\u91ce\u3067\u305d\u306e\u5fdc\u7528\u304c\u5e83\u304c\u3063\u3066\u304a\u308a\u3001\u9069\u5207\u306a\u30e2\u30c7\u30eb\u306e\u9078\u629e\u3068\u4eee\u5b9a\u306e\u78ba\u8a8d\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u30c7\u30fc\u30bf\u306e\u6301\u3064\u60c5\u5831\u3092\u6700\u5927\u9650\u306b\u5f15\u304d\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u81e8\u5e8a\u7814\u7a76\u3084\u751f\u7269\u5b66\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u540c\u3058\u88ab\u9a13\u8005\u304b\u3089\u8907\u6570\u56de\u6e2c\u5b9a\u3055\u308c\u305f\u30c7\u30fc\u30bf\uff08\u53cd\u5fa9\u6e2c\u5b9a\u30c7\u30fc\u30bf\uff09\u306f\u983b\u7e41\u306b\u767b\u5834\u3059\u308b\u3002\u3053\u306e\u3088\u3046\u306a\u30c7\u30fc\u30bf\u306f\u3001\u5f93\u6765\u306e\u7dda\u5f62\u56de\u5e30\u30e2\u30c7\u30eb\u3067\u306f\u9069\u5207\u306b\u89e3\u6790\u3067\u304d\u306a\u3044\u5834\u5408\u304c\u3042\u308b\u3002\u306a\u305c\u306a\u3089\u3001\u540c\u3058\u88ab\u9a13\u8005\u304b\u3089\u306e\u6e2c\u5b9a\u5024\u306f\u4e92\u3044\u306b\u76f8\u95a2 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":4039,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[59],"tags":[],"class_list":["post-4038","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-59"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2025\/06\/LMM_blood_pressure_over_time-scaled.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts\/4038","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/comments?post=4038"}],"version-history":[{"count":2,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts\/4038\/revisions"}],"predecessor-version":[{"id":4043,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts\/4038\/revisions\/4043"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/media\/4039"}],"wp:attachment":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/media?parent=4038"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/categories?post=4038"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/tags?post=4038"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}