{"id":4693,"date":"2026-08-08T22:03:09","date_gmt":"2026-08-08T13:03:09","guid":{"rendered":"https:\/\/best-biostatistics.com\/toukei-er\/?p=4693"},"modified":"2026-08-09T07:56:34","modified_gmt":"2026-08-08T22:56:34","slug":"handling-non-proportional-hazards-in-cox-regression-with-r-a-guide-to-rmst-stratification-and-time-varying-models","status":"publish","type":"post","link":"https:\/\/best-biostatistics.com\/toukei-er\/entry\/handling-non-proportional-hazards-in-cox-regression-with-r-a-guide-to-rmst-stratification-and-time-varying-models\/","title":{"rendered":"\u3010R\u8a00\u8a9e\u3011Cox\u56de\u5e30\u3067\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u304c\u602a\u3057\u3044\u6642\u306e\u5bfe\u51e6\u6cd5\uff01RMST\uff08\u5236\u9650\u4ed8\u304d\u5e73\u5747\u751f\u5b58\u6642\u9593\uff09\u306e\u4f7f\u3044\u65b9\u3068\u5c64\u5225\u5316\u30fb\u671f\u9593\u5206\u5272\u306e\u4f7f\u3044\u5206\u3051"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u8005<\/strong>: \u30ab\u30d7\u30e9\u30f3\u30de\u30a4\u30e4\u30fc\u66f2\u7dda\u3092\u63cf\u3044\u305f\u3089\u3001\u9014\u4e2d\u30672\u672c\u306e\u7dda\u304c\u4ea4\u5dee\uff08Cross\uff09\u3057\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u2026\u2026\u3002\u3053\u306e\u307e\u307eCox\u56de\u5e30\u3092\u884c\u3063\u3066\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u3092\u51fa\u3057\u3066\u3082\u5927\u4e08\u592b\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<\/blockquote>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>\u7d71\u8a08ER<\/strong>: \u66f2\u7dda\u304c\u4ea4\u5dee\u3057\u3066\u3044\u308b\uff08\uff1d\u30cf\u30b6\u30fc\u30c9\u6bd4\u304c\u6642\u9593\u3067\u5909\u52d5\u3057\u3066\u3044\u308b\uff09\u5834\u5408\u3001\u5358\u4e00\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\u3092\u51fa\u3059\u306e\u306f\u5371\u967a\u3067\u3059\uff01\u6700\u65b0\u306e\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u306b\u4f9d\u5b58\u3057\u306a\u3044<strong>RMST\uff08\u5236\u9650\u4ed8\u304d\u5e73\u5747\u751f\u5b58\u6642\u9593\uff09<\/strong>\u3092\u4f7f\u3046\u306e\u304c\u6700\u3082\u30b9\u30de\u30fc\u30c8\u3067\u3059\u3088\u3002<\/p>\n<\/blockquote>\n\n\n\n<!--more-->\n\n\n\n<p class=\"wp-block-paragraph\">\u81e8\u5e8a\u7814\u7a76\u3084\u89b3\u5bdf\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u751f\u5b58\u6642\u9593\u89e3\u6790\uff08\u30ab\u30d7\u30e9\u30f3\u30de\u30a4\u30e4\u30fc\u66f2\u7dda\u3084Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\uff09\u3092\u5b9f\u65bd\u3059\u308b\u969b\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u73fe\u8c61\u306b\u906d\u9047\u3057\u3066\u982d\u3092\u62b1\u3048\u305f\u7d4c\u9a13\u306f\u306a\u3044\u3060\u308d\u3046\u304b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u300c\u30ab\u30d7\u30e9\u30f3\u30de\u30a4\u30e4\u30fc\uff08KM\uff09\u66f2\u7dda\u3092\u63cf\u3044\u3066\u307f\u305f\u3089\u3001\u9014\u4e2d\u30672\u672c\u306e\u30e9\u30a4\u30f3\u304c\u5927\u304d\u304f\u4ea4\u5dee\uff08Cross\uff09\u3057\u3066\u3057\u307e\u3063\u305f\u300d<\/li>\n\n\n\n<li>\u300cSchoenfeld\u6b8b\u5dee\u30d7\u30ed\u30c3\u30c8\u3092\u63cf\u304f\u3068\u3001\u6c34\u5e73\u3067\u306f\u306a\u304f\u53f3\u80a9\u4e0a\u304c\u308a\uff0f\u53f3\u80a9\u4e0b\u304c\u308a\u306b\u659c\u3081\u306b\u50be\u3044\u3066\u3044\u308b\u300d<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u306f\u5927\u524d\u63d0\u3068\u3057\u3066\u300c\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u306e\u4eee\u5b9a\uff08Proportional Hazards Assumption\uff1aPH\u4eee\u5b9a\uff09\u300d\u3001\u3059\u306a\u308f\u3061\u6642\u9593\u306e\u7d4c\u904e\u306b\u3088\u3063\u30662\u7fa4\u9593\u306e\u30ea\u30b9\u30af\u6bd4\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4\uff09\u304c\u5909\u5316\u3057\u306a\u3044\u3068\u3044\u3046\u5f37\u3044\u4eee\u5b9a\u3092\u7f6e\u3044\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u751f\u5b58\u66f2\u7dda\u304c\u4ea4\u5dee\u3057\u3066\u3044\u308b\uff08\uff1d\u30cf\u30b6\u30fc\u30c9\u6bd4\u304c\u6642\u9593\u306b\u3088\u3063\u3066\u5909\u5316\u3057\u3066\u3044\u308b\uff09\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u7121\u7406\u3084\u308aCox\u56de\u5e30\u3092\u9069\u7528\u3057\u3066\u300c\u5358\u4e00\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08\u4f8b: HR = 0.85\uff09\u300d\u3092\u7b97\u51fa\u3057\u3066\u3057\u307e\u3046\u3068\u3001\u521d\u671f\u306e\u6cbb\u7642\u52b9\u679c\u3084\u5f8c\u671f\u306e\u9006\u8ee2\u73fe\u8c61\u304c\u5e73\u5747\u5316\u3055\u308c\u3001<strong>\u81e8\u5e8a\u7684\u306a\u771f\u5b9f\u3092\u4e0d\u5f53\u306b\u96a0\u853d\u30fb\u904e\u5c0f\u8a55\u4fa1\u3057\u3066\u3057\u307e\u3046\u5371\u967a\u6027<\/strong>\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>\u91cd\u8981\uff1a\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u306e\u78ba\u8a8d\u65b9\u6cd5<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u306e\u78ba\u8a8d\u306b\u304a\u3044\u3066<strong>\u300c\u4eee\u8aac\u691c\u5b9a\u306eP\u5024\u300d\u306b\u983c\u308a\u3059\u304e\u308b\u306e\u306f\u597d\u307e\u3057\u304f\u306a\u3044<\/strong>\u3002\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u3044\u3068\u4e0d\u9069\u683c\u3067\u3082\u6709\u610f\u306b\u306a\u308a\u306b\u304f\u304f\u3001\u9006\u306b\u5927\u30b5\u30f3\u30d7\u30eb\u3067\u306f\u308f\u305a\u304b\u306a\u30ba\u30ec\u3067\u3082\u6709\u610f\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u305f\u3081\u3067\u3042\u308b\u3002\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u306f\u3001Schoenfeld\u6b8b\u5dee\u30d7\u30ed\u30c3\u30c8\u306a\u3069\u306e<strong>\u300c\u30b0\u30e9\u30d5\u306b\u3088\u308b\u8996\u899a\u7684\u306a\u78ba\u8a8d\u300d\u3067\u5224\u5b9a\u3059\u308b\u306e\u304c\u7d71\u8a08\u5b66\u7684\u306a\u9244\u5247<\/strong>\u3067\u3042\u308b\u3002<\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u8a18\u4e8b\u3067\u306f\u3001Schoenfeld\u6b8b\u5dee\u30d7\u30ed\u30c3\u30c8\u7b49\u3067\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u304c\u602a\u3057\u3044\u3068\u5224\u5b9a\u3055\u308c\u305f\u969b\u306e\u300c4\u5927\u5bfe\u51e6\u6cd5\u3068\u4f7f\u3044\u5206\u3051\u30eb\u30fc\u30eb\u300d<strong>\u3092\u6574\u7406\u3057\u3001\u7279\u306b\u73fe\u4ee3\u306e\u81e8\u5e8a\u7814\u7a76\u3067\u6700\u63a8\u5968\u3055\u308c\u3066\u3044\u308b<\/strong>RMST\uff08\u5236\u9650\u4ed8\u304d\u5e73\u5747\u751f\u5b58\u6642\u9593\uff1aRestricted Mean Survival Time\uff09\u306e\u6982\u5ff5\u3068R\u3067\u306e\u5b9f\u8df5\u30b3\u30fc\u30c9\u3092\u5206\u304b\u308a\u3084\u3059\u304f\u89e3\u8aac\u3059\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u304c\u602a\u3057\u3044\u3068\u304d\u306e\u300c4\u5927\u5bfe\u51e6\u6cd5\u300d\u3068\u4f7f\u3044\u5206\u3051\u30c1\u30e3\u30fc\u30c8<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u304c\u4fdd\u305f\u308c\u3066\u3044\u306a\u3044\u5834\u5408\u3001\u6f20\u7136\u3068\u89e3\u6790\u3092\u9032\u3081\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u300c\u3069\u306e\u5909\u6570\u306e\u4eee\u5b9a\u304c\u7834\u7dbb\u3057\u3066\u3044\u308b\u304b\u300d\u306b\u5fdc\u3058\u3066\u9069\u5207\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u9078\u629e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1. \u4e3b\u306a\u5bfe\u51e6\u6cd5\u306e\u610f\u601d\u6c7a\u5b9a\u30d5\u30ed\u30fc<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u95a2\u5fc3\u306e\u3042\u308b\u4e3b\u8981\u306a\u300c\u66dd\u9732\u5909\u6570\uff08\u6cbb\u7642\u7fa4\u306a\u3069\uff09\u300d\u306e\u4eee\u5b9a\u304c\u7834\u7dbb\u3057\u3066\u3044\u308b\u5834\u5408<\/strong> \u2794 <strong>RMST\uff08\u5236\u9650\u4ed8\u304d\u5e73\u5747\u751f\u5b58\u6642\u9593\uff09<\/strong>\u3010\u7b2c\u4e00\u9078\u629e\u3011 \u307e\u305f\u306f <strong>\u671f\u9593\u5206\u5272\u30e2\u30c7\u30eb<\/strong><\/li>\n\n\n\n<li><strong>\u8abf\u6574\u7528\u306e\u300c\u80cc\u666f\u5171\u5909\u91cf\uff08\u5e74\u9f62\u30fb\u75c5\u671f\u30fb\u65bd\u8a2d\u306a\u3069\uff09\u300d\u306e\u4eee\u5b9a\u304c\u7834\u7dbb\u3057\u3066\u3044\u308b\u5834\u5408<\/strong> \u2794 <strong>\u5c64\u5225\u5316Cox\u56de\u5e30\uff08Stratified Cox Model\uff09<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">2. \u8abf\u6574\u7528\u5171\u5909\u91cf\u304c\u7834\u7dbb\u3057\u3066\u3044\u308b\u306a\u3089\u300c\u5c64\u5225\u5316Cox\u56de\u5e30\u300d<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3b\u8981\u306a\u66dd\u9732\u5909\u6570\uff08\u6cbb\u7642\u7fa4\uff09\u306e\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u306f\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u8abf\u6574\u7528\u5171\u5909\u91cf\uff08\u4f8b: \u75c5\u671f Stage \u3084\u65bd\u8a2d\u5dee\uff09\u306e\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u304c\u5d29\u308c\u3066\u3044\u308b\u5834\u5408\u306f\u3001<strong>\u5c64\u5225\u5316Cox\u56de\u5e30\uff08<code>strata()<\/code>\uff09<\/strong> \u3092\u7528\u3044\u308b\u306e\u304c\u6700\u3082\u30b9\u30de\u30fc\u30c8\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5c64\u5225\u5316Cox\u56de\u5e30\u306e\u8a73\u3057\u3044\u4ed5\u7d44\u307f\u3084R\u3067\u306e\u8a18\u8ff0\u6cd5\u3001<code>strata()<\/code> \u3092\u5165\u308c\u305f\u969b\u306b\u305d\u306e\u5909\u6570\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\u304c\u51fa\u529b\u3055\u308c\u306a\u304f\u306a\u308b\u4ed5\u69d8\u306b\u3064\u3044\u3066\u306f\u3001\u4ee5\u524d\u306b\u89e3\u8aac\u3057\u305f\u3053\u3061\u3089\u306e\u8a18\u4e8b\u3092\u53c2\u7167\u3057\u3066\u307b\u3057\u3044\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2794 <a href=\"https:\/\/best-biostatistics.com\/toukei-er\/entry\/complete-guide-to-stratified-cox-regression-in-r-why-hazard-ratios-disappear-with-strata-and-paper-reporting-standards\/\">\u5c64\u5225\u5316Cox\u56de\u5e30\u306e\u5b8c\u5168\u30ac\u30a4\u30c9\uff01strata()\u3067\u30cf\u30b6\u30fc\u30c9\u6bd4\u304c\u6d88\u3048\u308b\u7406\u7531\u304b\u3089\u8ad6\u6587\u306e\u8a18\u8ff0\u4f5c\u6cd5\u307e\u3067<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u306b\u4f9d\u5b58\u3057\u306a\u3044\u6700\u5148\u7aef\u306e\u624b\u6cd5\u300cRMST\uff08\u5236\u9650\u4ed8\u304d\u5e73\u5747\u751f\u5b58\u6642\u9593\uff09\u300d\u3068\u306f\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u66dd\u9732\u5909\u6570\uff08\u6cbb\u7642\u7fa4\uff09\u81ea\u4f53\u306e\u751f\u5b58\u66f2\u7dda\u304c\u4ea4\u5dee\u3057\u3066\u3044\u308b\u5834\u5408\u3001\u5358\u4e00\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\u3092\u5831\u544a\u3059\u308b\u3053\u3068\u306f\u7d71\u8a08\u5b66\u7684\u306b\u59a5\u5f53\u3067\u306f\u306a\u3044\u3002\u3053\u306e\u5c40\u9762\u3067\u6700\u3082\u63a8\u5968\u3055\u308c\u308b\u306e\u304c <strong>RMST\uff08Restricted Mean Survival Time\uff1a\u5236\u9650\u4ed8\u304d\u5e73\u5747\u751f\u5b58\u6642\u9593\uff09<\/strong> \u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1. RMST\u306e\u57fa\u672c\u7684\u306a\u8003\u3048\u65b9\uff08\u751f\u5b58\u66f2\u7dda\u306e\u4e0b\u9762\u7a4d\uff09<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u901a\u5e38\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\uff08Median Survival Time\uff09\u306f\u3001\u751f\u5b58\u7387\u304c50%\u306b\u9054\u3057\u306a\u3044\u3068\u7b97\u51fa\u3067\u304d\u306a\u3044\u3068\u3044\u3046\u30c7\u30e1\u30ea\u30c3\u30c8\u304c\u3042\u308b\u3002\u307e\u305f\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u306e\u4eee\u5b9a\u304c\u5fc5\u9808\u3068\u306a\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u306b\u5bfe\u3057\u3001RMST\u306f\u300c\u3042\u3089\u304b\u3058\u3081\u8a2d\u5b9a\u3057\u305f\u5236\u9650\u6642\u9593 $\\tau$\uff08\u30bf\u30a6\uff1a\u4f8b: 24\u30f6\u6708\u308436\u30f6\u6708\uff09\u307e\u3067\u306e\u3001\u30ab\u30d7\u30e9\u30f3\u30de\u30a4\u30e4\u30fc\u66f2\u7dda\u306e\u4e0b\u9762\u7a4d\uff08\u7a4d\u5206\u306e\u9762\u7a4d\uff09\u300d\u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6570\u5b66\u7684\u306b\u306f\u300c\u89b3\u5bdf\u958b\u59cb\u304b\u3089\u6642\u9593 $\\tau$ \u307e\u3067\u306e\u5e73\u5747\u751f\u5b58\u671f\u9593\u300d\u3092\u610f\u5473\u3057\u3066\u304a\u308a\u3001\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u306e\u4eee\u5b9a\u306b\u306f\u4e00\u5207\u4f9d\u5b58\u3057\u306a\u3044\uff08\u30ce\u30f3\u30d1\u30e9\u30e1\u30c8\u30ea\u30c3\u30af \/ \u30bb\u30df\u30d1\u30e9\u30e1\u30c8\u30ea\u30c3\u30af\u624b\u6cd5\uff09\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2. \u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u306b\u5bfe\u3059\u308bRMST\u306e\u81e8\u5e8a\u7684\u30e1\u30ea\u30c3\u30c8<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u306e\u4eee\u5b9a\u304c\u4e0d\u8981<\/strong>: \u66f2\u7dda\u304c\u9014\u4e2d\u3067\u4ea4\u5dee\u3057\u3066\u3044\u3066\u3082\u3001\u521d\u671f\u306b\u52b9\u679c\u304c\u9045\u308c\u3066\u51fa\u73fe\uff08Delayed Onset\uff09\u3057\u3066\u3082\u554f\u984c\u306a\u304f\u89e3\u6790\u3067\u304d\u308b\u3002<\/li>\n\n\n\n<li><strong>\u76f4\u611f\u7684\u306b\u81e8\u5e8a\u52b9\u679c\u3092\u7406\u89e3\u3057\u3084\u3059\u3044<\/strong>: \u300cA\u7fa4\u306fB\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u300124\u30f6\u6708\u306e\u6642\u70b9\u307e\u3067\u306b<strong>\u5e73\u5747\u3057\u30662.3\u30f6\u6708\u9577\u304f\u751f\u5b58\u3067\u304d\u305f<\/strong>\uff08RMST Difference = 2.3 months\uff09\u300d\u3068\u3044\u3046\u3088\u3046\u306b\u3001\u6642\u9593\u5358\u4f4d\u3067\u52b9\u679c\u306e\u5dee\u3092\u76f4\u611f\u7684\u306b\u6349\u3048\u3089\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd1\u5e74\u3001\u304c\u3093\u9818\u57df\u306b\u304a\u3051\u308b\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\uff08ICI\uff09\u306e\u6cbb\u9a13\u306a\u3069\u3067\u3001\u52b9\u679c\u306e\u767a\u73fe\u9045\u5ef6\u306b\u3088\u308b\u751f\u5b58\u66f2\u7dda\u306e\u4ea4\u5dee\u304c\u983b\u767a\u3057\u305f\u3053\u3068\u304b\u3089\u3001FDA\u3084\u4e3b\u8981\u533b\u5b66\u8a8c\uff08NEJM\u3084JCO\u7b49\uff09\u3067\u3082\u4e3b\u8981\u30fb\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u3068\u3057\u3066RMST\u306e\u5831\u544a\u304c\u5f37\u304f\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<div id=\"biost-4137552632\" class=\"biost- biost-entity-placement\"><p style=\"text-align: center;\"><span style=\"font-size: 20px;\"><strong><a href=\"https:\/\/best-biostatistics.com\/kmhl\">\uff1e\uff1e\u3082\u3046\u7d71\u8a08\u3067\u60a9\u3080\u306e\u306f\u7d42\u308f\u308a\u306b\u3057\u307e\u305b\u3093\u304b\uff1f\u00a0<\/a><\/strong><\/span><\/p>\r\n<a href=\"https:\/\/best-biostatistics.com\/kmhl\"><img class=\"aligncenter wp-image-2794 size-full\" src=\"https:\/\/best-biostatistics.com\/wp\/wp-content\/uploads\/2023\/11\/bn_r_03.png\" alt=\"\" width=\"500\" height=\"327\" \/><\/a>\r\n<p style=\"text-align: center;\"><span style=\"color: #ff0000; font-size: 20px;\"><strong><span class=\"marker2\">\u21911\u4e07\u4eba\u4ee5\u4e0a\u306e\u533b\u7642\u5f93\u4e8b\u8005\u304c\u8cfc\u8aad\u4e2d<\/span><\/strong><\/span><\/p><\/div><h2 class=\"wp-block-heading\">\u3010\u5b9f\u8df5\u3011R\u3067RMST\u89e3\u6790\u3092\u5b9f\u884c\u3059\u308b\uff08<code>survRM2<\/code> \u30d1\u30c3\u30b1\u30fc\u30b8\uff09<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">R\u3067RMST\u89e3\u6790\u3092\u884c\u3046\u306b\u306f\u3001\u5c02\u7528\u30d1\u30c3\u30b1\u30fc\u30b8\u3067\u3042\u308b <strong><code>survRM2<\/code><\/strong> \u3092\u4f7f\u7528\u3059\u308b\u306e\u304c\u6700\u3082\u7c21\u5358\u3067\u78ba\u5b9f\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1. \u5236\u9650\u6642\u9593 $\\tau$\uff08\u30bf\u30a6\uff09\u306e\u6c7a\u3081\u65b9\u3068\u8ad6\u6587\u5831\u544a\u306e\u6ce8\u610f\u70b9<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">RMST\u3092\u7b97\u51fa\u3059\u308b\u4e0a\u3067\u6700\u3082\u91cd\u8981\u306a\u306e\u304c\u3001<strong>\u5236\u9650\u6642\u9593 <\/strong>$\\tau$<strong>\uff08<code>tau<\/code>\uff09\u306e\u8a2d\u5b9a<\/strong>\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>\u67fb\u8aad\u8005\u306e\u8996\u70b9\uff1a\u5236\u9650\u6642\u9593<\/strong>$\\tau$<strong>\uff08tau\uff09\u306e\u8a2d\u5b9a\u6839\u62e0<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">$\\tau$\u306e\u5024\u306f\u3001P-hacking\uff08\u5f8c\u51fa\u3057\u3067\u306eP\u5024\u8abf\u6574\uff09\u3092\u7591\u308f\u308c\u306a\u3044\u3088\u3046\u3001\u539f\u5247\u3068\u3057\u3066<strong>\u300c\u89e3\u6790\u3092\u884c\u3046\u524d\u306b\u30d7\u30ed\u30c8\u30b3\u30eb\u3067\u898f\u5b9a\u3057\u3066\u304a\u304f\u300d<\/strong>\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u308b\u3002\u5b9f\u52d9\u4e0a\u306e\u6a19\u6e96\u7684\u306a\u8a2d\u5b9a\u57fa\u6e96\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4e21\u7fa4\u306e\u6700\u5c0f\u306e\u6700\u5927\u8ffd\u8de1\u671f\u9593<\/strong>: \u5404\u7fa4\u306e\u6700\u7d42\u89b3\u5bdf\u6642\u70b9\uff08\u6253\u5207\u308a\u3092\u542b\u3080\u6700\u5927\u8ffd\u8de1\u6642\u9593\uff09\u306e\u3046\u3061\u3001\u5c0f\u3055\u3044\u65b9\u306e\u5024\u3092\u8d85\u3048\u306a\u3044\u7bc4\u56f2\u3067\u8a2d\u5b9a\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u81e8\u5e8a\u7684\u59a5\u5f53\u6027<\/strong>: 24\u30f6\u6708\u300136\u30f6\u6708\u300160\u30f6\u6708\u306a\u3069\u3001\u75be\u60a3\u306e\u4e88\u5f8c\u3068\u3057\u3066\u81e8\u5e8a\u7684\u306b\u610f\u5473\u306e\u3042\u308b\u6642\u70b9\u306b\u4e38\u3081\u3066\u8a2d\u5b9a\u3059\u308b\u3002<\/li>\n<\/ul>\n<\/blockquote>\n\n\n\n<h3 class=\"wp-block-heading\">2. <code>survRMST::rmst2()<\/code> \u306b\u3088\u308b\u89e3\u6790\u30b3\u30fc\u30c9\u3068\u51fa\u529b\u306e\u8aad\u307f\u65b9<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u3042\u3089\u304b\u3058\u3081\u30d1\u30c3\u30b1\u30fc\u30b8\u3092\u8aad\u307f\u8fbc\u307f\u3001\u30b5\u30f3\u30d7\u30eb\u30c7\u30fc\u30bf\u3067\u89e3\u6790\u3092\u5b9f\u884c\u3057\u3066\u307f\u3088\u3046\u3002<\/p>\n\n\n\n<pre class=\"wp-block-code\"><code>library(tidyverse)\nlibrary(survival)\nlibrary(survminer)\nlibrary(survRM2) # RMST\u89e3\u6790\u7528\u30d1\u30c3\u30b1\u30fc\u30b8\n\n# \u30b5\u30f3\u30d7\u30eb\u30c7\u30fc\u30bf\u306e\u4f5c\u6210\uff08\u751f\u5b58\u66f2\u7dda\u304c\u9014\u4e2d\u3067\u4ea4\u5dee\u3059\u308b\u30c7\u30fc\u30bf\uff09\nset.seed(789)\nn &lt;- 200\ndf_cross &lt;- tibble(\n  id     = 1:n,\n  treat  = factor(sample(c(\"Control\", \"Treatment\"), n, replace = TRUE)),\n  # \u521d\u671f\u306fControl\u304c\u512a\u52e2\u3060\u304c\u3001\u5f8c\u534a\u3067Treatment\u304c\u9006\u8ee2\u3059\u308b\u8a2d\u5b9a\n  time   = rexp(n, rate = if_else(treat == \"Control\", 0.04, 0.06)),\n  status = sample(c(0, 1), n, replace = TRUE, prob = c(0.2, 0.8))\n)\n\n# 1. Schoenfeld\u6b8b\u5dee\u30d7\u30ed\u30c3\u30c8\u3067\u4eee\u5b9a\u306e\u78ba\u8a8d\uff08\u8996\u899a\u7684\u78ba\u8a8d\uff09\nfit_cox &lt;- coxph(Surv(time, status) ~ treat, data = df_cross)\ncz &lt;- cox.zph(fit_cox)\nggcoxzph(cz) # \u30d7\u30ed\u30c3\u30c8\u306e\u30e9\u30a4\u30f3\u304c\u6c34\u5e73\u3067\u306a\u304f\u659c\u3081\u306b\u50be\u3044\u3066\u3044\u308b\u3053\u3068\u3092\u8996\u899a\u7684\u306b\u78ba\u8a8d\n\n# 2. RMST\u89e3\u6790\u306e\u5b9f\u884c\uff08\u5236\u9650\u6642\u9593 tau \u3092 30 \u30ab\u6708\u306b\u8a2d\u5b9a\uff09\nrmst_res &lt;- rmst2(\n  time    = df_cross$time,\n  status  = df_cross$status,\n  arm     = if_else(df_cross$treat == \"Treatment\", 1, 0), # 1\/0 \u306e\u4e8c\u5024\u306b\u6307\u5b9a\n  tau     = 30 # \u5236\u9650\u6642\u9593 tau\n)\n\n# \u7d50\u679c\u306e\u78ba\u8a8d\nprint(rmst_res)\n<\/code><\/pre>\n\n\n\n<h3 class=\"wp-block-heading\">\u51fa\u529b\u7d50\u679c\u306e\u8aad\u307f\u89e3\u304d\uff08<code>rmst2<\/code> \u306e\u4e3b\u8981\u51fa\u529b\uff09<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><code>print(rmst_res)<\/code> \u3092\u5b9f\u884c\u3059\u308b\u3068\u3001\u4e3b\u306b\u4ee5\u4e0b\u306e2\u3064\u306e\u30c6\u30fc\u30d6\u30eb\u304c\u51fa\u529b\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>RMST per group\uff08\u5404\u7fa4\u306eRMST\u63a8\u5b9a\u91cf\uff09<\/strong>:\u5404\u7fa4\u306b\u304a\u3051\u308b $\\tau = 30$ \u307e\u3067\u306e\u5e73\u5747\u751f\u5b58\u6642\u9593\uff08<code>RMST<\/code>\uff09\u3068\u5e73\u5747\u751f\u5b58\u4e0d\u80fd\u6642\u9593\uff08<code>RMTL: Restricted Mean Time Lost<\/code>\uff09\u304c\u7b97\u51fa\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>Between-group contrast\uff08\u7fa4\u9593\u6bd4\u8f03\uff09<\/strong>:\n<ul class=\"wp-block-list\">\n<li><strong><code>RMST (arm=1) - RMST (arm=0)<\/code>\uff08RMST\u306e\u5dee\uff09<\/strong>: \u4ecb\u5165\u7fa4\u3068\u5bfe\u7167\u7fa4\u306e\u5e73\u5747\u751f\u5b58\u6642\u9593\u306e\u5dee\u3068\u305d\u306e95%\u4fe1\u983c\u533a\u9593\u30fbP\u5024\u3002\u8ad6\u6587\u3067\u6700\u3082\u4e3b\u8981\u306a\u6210\u679c\u3068\u3057\u3066\u5831\u544a\u3059\u308b\u6307\u6a19\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong><code>RMST (arm=1) \/ RMST (arm=0)<\/code>\uff08RMST\u306e\u6bd4\uff09<\/strong>: \u7fa4\u9593\u306e\u6bd4\u7387\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">\u305d\u306e\u4ed6\u306e\u5bfe\u51e6\u6cd5\uff1a\u671f\u9593\u5206\u5272\u30e2\u30c7\u30eb\uff08\u6642\u9593\u4f9d\u5b58\u6027\u4fc2\u6570\uff09\u3068\u30e9\u30f3\u30c9\u30de\u30fc\u30af\u89e3\u6790<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u66dd\u9732\u5909\u6570\u306ePH\u4eee\u5b9a\u304c\u7834\u7dbb\u3057\u3066\u3044\u308b\u969b\u3001RMST\u4ee5\u5916\u306e\u4ee3\u66ff\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u4ee5\u4e0b\u306e2\u3064\u3082\u9078\u629e\u80a2\u3068\u306a\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1. \u671f\u9593\u5206\u5272\u30e2\u30c7\u30eb\uff080\u301c6\u30f6\u6708\u30016\u30f6\u6708\u4ee5\u964d\u306a\u3069\uff09<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u89b3\u5bdf\u671f\u9593\u3092\u8907\u6570\u306e\u6642\u9593\u533a\u9593\uff08\u4f8b: \u300c0\u301c6\u30f6\u6708\u300d\u3068\u300c6\u30f6\u6708\u4ee5\u964d\u300d\uff09\u306b\u5206\u5272\u3057\u3001<strong>\u533a\u9593\u3054\u3068\u306b\u7570\u306a\u308b2\u3064\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR1, HR2\uff09\u3092\u63a8\u5b9a\u30fb\u5831\u544a\u3059\u308b\u624b\u6cd5<\/strong>\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u300c\u6cbb\u7642\u958b\u59cb\u76f4\u5f8c\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f HR = 1.25 \u3067\u3042\u3063\u305f\u304c\u30016\u30f6\u6708\u4ee5\u964d\u306f HR = 0.55 \u307e\u3067\u4f4e\u4e0b\u3057\u3066\u6709\u610f\u306a\u6cbb\u7642\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u305f\u300d\u3068\u3044\u3063\u305f\u6642\u9593\u7d4c\u904e\u306b\u4f34\u3046\u52b9\u679c\u306e\u5909\u5316\u3092\u5b9a\u91cf\u5316\u3057\u305f\u3044\u5834\u5408\u306b\u6709\u52b9\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2. \u30e9\u30f3\u30c9\u30de\u30fc\u30af\u89e3\u6790\uff08Landmark Analysis\uff09<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u5b9a\u306e\u6642\u70b9\uff08\u4f8b: \u6cbb\u7642\u958b\u59cb\u5f8c3\u30f6\u6708\u6642\u70b9\u306a\u3069\uff1d\u30e9\u30f3\u30c9\u30de\u30fc\u30af\u6642\u70b9\uff09\u3092\u8a2d\u5b9a\u3057\u3001<strong>\u300c\u305d\u306e\u6642\u70b9\u307e\u3067\u751f\u5b58\u3057\u3066\u3044\u305f\u60a3\u8005\u300d\u306e\u307f\u306b\u5bfe\u8c61\u3092\u7d5e\u308a\u8fbc\u3093\u3067\u3001\u305d\u308c\u4ee5\u964d\u306e\u751f\u5b58\u6642\u9593\u3092\u518d\u89e3\u6790\u3059\u308b\u624b\u6cd5<\/strong>\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6cbb\u7642\u521d\u671f\u306e\u30a4\u30cb\u30b7\u30e3\u30eb\u30c9\u30ed\u30c3\u30d7\u30a2\u30a6\u30c8\uff08\u521d\u671f\u6b7b\u4ea1\uff09\u306e\u5f71\u97ff\u3092\u9664\u5916\u3057\u3066\u3001\u9577\u671f\u751f\u5b58\u4f8b\u306b\u304a\u3051\u308b\u6cbb\u7642\u52b9\u679c\u3092\u6b63\u3057\u304f\u8a55\u4fa1\u3057\u305f\u3044\u5834\u5408\u306b\u6709\u7528\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u67fb\u8aad\u8005\uff08Reviewer\uff09\u3092\u7d0d\u5f97\u3055\u305b\u308b\u8ad6\u6587\u30fb\u5b66\u4f1a\u767a\u8868\u3067\u306e\u8a18\u8ff0\u4f5c\u6cd5<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">RMST\u89e3\u6790\u3092\u8ad6\u6587\u3078\u5c0e\u5165\u3059\u308b\u969b\u306e\u6a19\u6e96\u7684\u306a\u82f1\u6587\u8a18\u8ff0\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u3092\u4ee5\u4e0b\u306b\u793a\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u89e3\u6790\u65b9\u6cd5\uff08Methods\uff09\u306e\u82f1\u6587\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8<\/h3>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><em>&#8220;Because the proportional hazards assumption was violated based on graphical inspection of Schoenfeld residuals, restricted mean survival time (RMST) analysis was performed as the primary comparison between treatment groups. The restriction time tau was pre-specified at 24 months based on the minimum of the maximum follow-up times across groups.&#8221;<\/em><\/p>\n<\/blockquote>\n\n\n\n<h3 class=\"wp-block-heading\">\u7d50\u679c\u6b04\uff08Results \/ Table \u811a\u6ce8\uff09\u306e\u82f1\u6587\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8<\/h3>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><em>&#8220;At 24 months, the RMST was 18.5 months in the treatment group and 15.2 months in the control group. The difference in RMST was 3.3 months (95% CI, 1.1 to 5.5 months; p = 0.003), favoring the treatment group.&#8221;<\/em><\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">\u3010\u307e\u3068\u3081\u3011\u30b3\u30d4\u30da\u3067\u52d5\u304f\uff01\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u7834\u7dbb\u6642\u306eRMST\u89e3\u6790\u4e00\u62ec\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u8a18\u4e8b\u3067\u89e3\u8aac\u3057\u305f\u300cSchoenfeld\u6b8b\u5dee\u30d7\u30ed\u30c3\u30c8\u306b\u3088\u308b\u30b0\u30e9\u30d5\u78ba\u8a8d \u2794 <code>survRM2<\/code> \u306b\u3088\u308b\u89e3\u6790 \u2794 \u7d50\u679c\u30d7\u30ed\u30c3\u30c8\u306e\u63cf\u753b\u300d\u3092\u4e00\u62ec\u3067\u5b9f\u884c\u3067\u304d\u308b\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u30b3\u30fc\u30c9\u3092\u4ee5\u4e0b\u306b\u307e\u3068\u3081\u305f\u3002\u81ea\u8eab\u306e\u624b\u5143\u306e\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u540d\u30fb\u5909\u6570\u540d\u306b\u7f6e\u304d\u63db\u3048\u3066\u6d3b\u7528\u3057\u3066\u307b\u3057\u3044\u3002<\/p>\n\n\n\n<pre class=\"wp-block-code\"><code># === \u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u7834\u7dbb\u6642\u306e RMST \u89e3\u6790\u4e00\u62ec\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8 ===\nlibrary(tidyverse)\nlibrary(survival)\nlibrary(survminer)\nlibrary(survRM2)\n\n# Step 1: Schoenfeld\u6b8b\u5dee\u30d7\u30ed\u30c3\u30c8\u3067\u4eee\u5b9a\u306e\u5d29\u308c\u3092\u8996\u899a\u7684\u306b\u78ba\u8a8d\nfit_cox &lt;- coxph(Surv(time, status) ~ treat, data = df)\ncz &lt;- cox.zph(fit_cox)\nggcoxzph(cz) # \u30b0\u30e9\u30d5\u306e\u30e9\u30a4\u30f3\u304c\u50be\u3044\u3066\u3044\u308b\u304b\u8996\u899a\u7684\u306b\u78ba\u8a8d\n\n# Step 2: RMST\u89e3\u6790\u306e\u5b9f\u884c\uff08\u203b tau \u306e\u5024\u306f\u30d7\u30ed\u30c3\u30c8\u3084\u81e8\u5e8a\u7684\u80cc\u666f\u306b\u57fa\u3065\u304d\u4e8b\u524d\u8a2d\u5b9a\uff09\n# arm \u306f 1\uff08\u4ecb\u5165\u7fa4\uff09\/ 0\uff08\u5bfe\u7167\u7fa4\uff09\u306b\u5909\u63db\narm_binary &lt;- if_else(df$treat == \"Treatment\", 1, 0)\n\nrmst_fit &lt;- rmst2(\n  time   = df$time,\n  status = df$status,\n  arm    = arm_binary,\n  tau    = 24 # \u5236\u9650\u6642\u9593 tau\uff08\u4f8b: 24\u30f6\u6708\uff09\n)\n\n# Step 3: RMST\u306e\u89e3\u6790\u7d50\u679c\u8868\u793a\uff08RMST\u306e\u5dee\u30fb\u6bd4\u306e\u78ba\u8a8d\uff09\nprint(rmst_fit)\n\n# Step 4: RMST\u30d7\u30ed\u30c3\u30c8\u306e\u63cf\u753b\uff08\u4e0b\u9762\u7a4d\u306e\u53ef\u8996\u5316\uff09\nplot(rmst_fit, xlab = \"Time (Months)\", ylab = \"Survival Probability\")\n<\/code><\/pre>\n\n\n\n<p class=\"wp-block-paragraph\">\u751f\u5b58\u66f2\u7dda\u306e\u4ea4\u5dee\u3084\u6b8b\u5dee\u30d7\u30ed\u30c3\u30c8\u306e\u50be\u304d\u3092\u898b\u3066\u300c\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u6027\u304c\u5d29\u308c\u3066\u3044\u308b\u304b\u3089\u89e3\u6790\u304c\u3067\u304d\u306a\u3044\u300d\u3068\u8ae6\u3081\u308b\u5fc5\u8981\u306f\u306a\u3044\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u66dd\u9732\u5909\u6570\uff08\u6cbb\u7642\u7fa4\uff09\u306e\u4eee\u5b9a\u304c\u5d29\u308c\u305f\u969b\u306fRMST\u3092\u5c0e\u5165\u3057\u3001\u76f4\u611f\u7684\u3067\u8aac\u5f97\u529b\u306e\u3042\u308b\u89e3\u6790\u7d50\u679c\u3092\u8ad6\u6587\u3078\u7d44\u307f\u8fbc\u3093\u3067\u3044\u3053\u3046\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u304a\u3059\u3059\u3081\u66f8\u7c4d<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/amzn.to\/4wdavCg\">\u8ab0\u3082\u6559\u3048\u3066\u304f\u308c\u306a\u304b\u3063\u305f\u3000\u533b\u7642\u7d71\u8a08\u306e\u4f7f\u3044\u5206\u3051\u301c\u8ff7\u3044\u3084\u3059\u3044\u89e3\u6790\u624b\u6cd5\u306e\u9078\u3073\u65b9\u304c\uff0cR\u3067\u5b9f\u611f\u3057\u306a\u304c\u3089\u308f\u304b\u308b\uff01<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7814\u7a76\u8005: \u30ab\u30d7\u30e9\u30f3\u30de\u30a4\u30e4\u30fc\u66f2\u7dda\u3092\u63cf\u3044\u305f\u3089\u3001\u9014\u4e2d\u30672\u672c\u306e\u7dda\u304c\u4ea4\u5dee\uff08Cross\uff09\u3057\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u2026\u2026\u3002\u3053\u306e\u307e\u307eCox\u56de\u5e30\u3092\u884c\u3063\u3066\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u3092\u51fa\u3057\u3066\u3082\u5927\u4e08\u592b\u3067\u3057\u3087\u3046\u304b\uff1f \u7d71\u8a08ER: \u66f2\u7dda\u304c\u4ea4\u5dee\u3057\u3066\u3044\u308b\uff08\uff1d\u30cf\u30b6\u30fc\u30c9\u6bd4\u304c\u6642 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":4694,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[118],"tags":[],"class_list":["post-4693","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-118"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2026\/08\/RMST\u5236\u9650\u4ed8\u304d\u5e73\u5747\u751f\u5b58\u6642\u9593-scaled.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts\/4693","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/comments?post=4693"}],"version-history":[{"count":2,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts\/4693\/revisions"}],"predecessor-version":[{"id":4696,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts\/4693\/revisions\/4696"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/media\/4694"}],"wp:attachment":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/media?parent=4693"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/categories?post=4693"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/tags?post=4693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}