{"id":521,"date":"2018-08-08T19:30:29","date_gmt":"2018-08-08T10:30:29","guid":{"rendered":"https:\/\/best-biostatistics.com\/toukei-er\/entry\/how-to-determine-sample-size-in-non-inferiority-trial-with-cox-regression\/"},"modified":"2024-10-13T20:59:11","modified_gmt":"2024-10-13T11:59:11","slug":"how-to-determine-sample-size-in-non-inferiority-trial-with-cox-regression","status":"publish","type":"post","link":"https:\/\/best-biostatistics.com\/toukei-er\/entry\/how-to-determine-sample-size-in-non-inferiority-trial-with-cox-regression\/","title":{"rendered":"R \u3067\u975e\u52a3\u6027\u306e\u751f\u5b58\u6642\u9593\u89e3\u6790\u306b\u5fc5\u8981\u306a\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u3092\u8a08\u7b97\u3059\u308b\u65b9\u6cd5"},"content":{"rendered":"\n<p>\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97<\/p>\n\n\n\n<p>\u751f\u5b58\u6642\u9593\u30c7\u30fc\u30bf\u306e\u5834\u5408<\/p>\n\n\n\n<!--more-->\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97-\u751f\u5b58\u6642\u9593\u30c7\u30fc\u30bf\u306e\u5834\u5408-\u4f8b-1\">\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97 \u751f\u5b58\u6642\u9593\u30c7\u30fc\u30bf\u306e\u5834\u5408 \u4f8b 1<\/h2>\n\n\n\n<p>\u5404\u8a18\u53f7\u306e\u610f\u5473\u306f\u4ee5\u4e0b\u306e\u3068\u304a\u308a\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>t\uff1a\u89b3\u5bdf\u671f\u9593\u3002<\/li>\n\n\n\n<li>S1\u3068S0\uff1a\u305d\u308c\u305e\u308c\u6cbb\u7642\u7fa4\u3068\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u306e\u751f\u5b58\u7387\u3002<\/li>\n\n\n\n<li>dF\uff1aFreedman\u306e\u65b9\u6cd5\u306b\u3088\u308b\u5404\u7fa4\u5fc5\u8981\u306a\u6b7b\u4ea1\u75c7\u4f8b\u6570\u3002<\/li>\n\n\n\n<li>dS\uff1aSchoenfeld\u306e\u65b9\u6cd5\u306b\u3088\u308b\u5404\u7fa4\u5fc5\u8981\u306a\u6b7b\u4ea1\u75c7\u4f8b\u6570\u3002<\/li>\n\n\n\n<li>Delta.S0\uff1a\u975e\u52a3\u6027\u30de\u30fc\u30b8\u30f3\u3002<\/li>\n<\/ul>\n\n\n\n<p>R \u30b9\u30af\u30ea\u30d7\u30c8\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u306a\u308b\u3002<\/p>\n\n\n\n<pre class=\"wp-block-code\"><code>sample.size.cox.noninf <span class=\"synStatement\">&lt;-<\/span> <span class=\"synType\">function<\/span><span class=\"synSpecial\">(<\/span>t<span class=\"synSpecial\">,<\/span>S1<span class=\"synSpecial\">,<\/span>S0<span class=\"synSpecial\">,<\/span>Delta.S0<span class=\"synSpecial\">,<\/span>\nalternative<span class=\"synStatement\">=<\/span><span class=\"synIdentifier\">c<\/span><span class=\"synSpecial\">(<\/span><span class=\"synConstant\">\"one.sided\"<\/span><span class=\"synSpecial\">,<\/span><span class=\"synConstant\">\"two.sided\"<\/span><span class=\"synSpecial\">),<\/span>power<span class=\"synStatement\">=<\/span><span class=\"synConstant\">.8<\/span><span class=\"synSpecial\">,<\/span>\nsig.level<span class=\"synStatement\">=<\/span><span class=\"synConstant\">.05<\/span><span class=\"synSpecial\">){<\/span>\nalternative <span class=\"synStatement\">&lt;-<\/span> <span class=\"synIdentifier\">match.arg<\/span><span class=\"synSpecial\">(<\/span>alternative<span class=\"synSpecial\">)<\/span>\ntside <span class=\"synStatement\">&lt;-<\/span> <span class=\"synIdentifier\">switch<\/span><span class=\"synSpecial\">(<\/span>alternative<span class=\"synSpecial\">,<\/span> one.sided<span class=\"synStatement\">=<\/span><span class=\"synConstant\">1<\/span><span class=\"synSpecial\">,<\/span> two.sided<span class=\"synStatement\">=<\/span><span class=\"synConstant\">2<\/span><span class=\"synSpecial\">)<\/span>\nbeta <span class=\"synStatement\">&lt;-<\/span> <span class=\"synIdentifier\">log<\/span><span class=\"synSpecial\">(<\/span><span class=\"synIdentifier\">log<\/span><span class=\"synSpecial\">(<\/span>S1<span class=\"synSpecial\">)<\/span><span class=\"synStatement\">\/<\/span><span class=\"synIdentifier\">log<\/span><span class=\"synSpecial\">(<\/span>S0<span class=\"synSpecial\">))<\/span>\nH1 <span class=\"synStatement\">&lt;-<\/span> <span class=\"synStatement\">-<\/span><span class=\"synConstant\">1<\/span><span class=\"synStatement\">*<\/span><span class=\"synIdentifier\">log<\/span><span class=\"synSpecial\">(<\/span>S1<span class=\"synSpecial\">)<\/span><span class=\"synStatement\">\/<\/span>t\nH0 <span class=\"synStatement\">&lt;-<\/span> <span class=\"synStatement\">-<\/span><span class=\"synConstant\">1<\/span><span class=\"synStatement\">*<\/span><span class=\"synIdentifier\">log<\/span><span class=\"synSpecial\">(<\/span>S0<span class=\"synSpecial\">)<\/span><span class=\"synStatement\">\/<\/span>t\nHR <span class=\"synStatement\">&lt;-<\/span> H1<span class=\"synStatement\">\/<\/span>H0\nH0.prime <span class=\"synStatement\">&lt;-<\/span> <span class=\"synStatement\">-<\/span><span class=\"synConstant\">1<\/span><span class=\"synStatement\">*<\/span><span class=\"synIdentifier\">log<\/span><span class=\"synSpecial\">(<\/span>S0<span class=\"synStatement\">-<\/span>Delta.S0<span class=\"synSpecial\">)<\/span><span class=\"synStatement\">\/<\/span>t\nHR.prime <span class=\"synStatement\">&lt;-<\/span> H1<span class=\"synStatement\">\/<\/span>H0.prime\nZa <span class=\"synStatement\">&lt;-<\/span> <span class=\"synIdentifier\">qnorm<\/span><span class=\"synSpecial\">(<\/span>sig.level<span class=\"synStatement\">\/<\/span>tside<span class=\"synSpecial\">,<\/span> lower.tail<span class=\"synStatement\">=<\/span><span class=\"synConstant\">FALSE<\/span><span class=\"synSpecial\">)<\/span>\nZb <span class=\"synStatement\">&lt;-<\/span> <span class=\"synIdentifier\">qnorm<\/span><span class=\"synSpecial\">(<\/span>power<span class=\"synSpecial\">)<\/span>\ndF <span class=\"synStatement\">&lt;-<\/span> <span class=\"synSpecial\">(<\/span>Za<span class=\"synStatement\">+<\/span>Zb<span class=\"synSpecial\">)<\/span><span class=\"synStatement\">^<\/span><span class=\"synConstant\">2<\/span><span class=\"synStatement\">*<\/span><span class=\"synSpecial\">(<\/span>HR.prime<span class=\"synStatement\">+<\/span><span class=\"synConstant\">1<\/span><span class=\"synSpecial\">)<\/span><span class=\"synStatement\">^<\/span><span class=\"synConstant\">2<\/span><span class=\"synStatement\">\/<\/span><span class=\"synSpecial\">(<\/span><span class=\"synConstant\">2<\/span><span class=\"synStatement\">*<\/span><span class=\"synSpecial\">(<\/span>HR.prime<span class=\"synStatement\">-<\/span><span class=\"synConstant\">1<\/span><span class=\"synSpecial\">)<\/span><span class=\"synStatement\">^<\/span><span class=\"synConstant\">2<\/span><span class=\"synSpecial\">)<\/span>\nnF <span class=\"synStatement\">&lt;-<\/span> dF<span class=\"synStatement\">\/<\/span><span class=\"synSpecial\">(((<\/span><span class=\"synConstant\">1<\/span><span class=\"synStatement\">-<\/span>S1<span class=\"synSpecial\">)<\/span><span class=\"synStatement\">+<\/span><span class=\"synSpecial\">(<\/span><span class=\"synConstant\">1<\/span><span class=\"synStatement\">-<\/span>S0<span class=\"synSpecial\">))<\/span><span class=\"synStatement\">\/<\/span><span class=\"synConstant\">2<\/span><span class=\"synSpecial\">)<\/span>\ndS <span class=\"synStatement\">&lt;-<\/span> <span class=\"synConstant\">2<\/span><span class=\"synStatement\">*<\/span><span class=\"synSpecial\">(<\/span>Za<span class=\"synStatement\">+<\/span>Zb<span class=\"synSpecial\">)<\/span><span class=\"synStatement\">^<\/span><span class=\"synConstant\">2<\/span><span class=\"synStatement\">\/<\/span><span class=\"synSpecial\">((<\/span><span class=\"synIdentifier\">log<\/span><span class=\"synSpecial\">(<\/span>HR.prime<span class=\"synSpecial\">))<\/span><span class=\"synStatement\">^<\/span><span class=\"synConstant\">2<\/span><span class=\"synSpecial\">)<\/span>\nnS <span class=\"synStatement\">&lt;-<\/span> dS<span class=\"synStatement\">\/<\/span><span class=\"synSpecial\">(((<\/span><span class=\"synConstant\">1<\/span><span class=\"synStatement\">-<\/span>S1<span class=\"synSpecial\">)<\/span><span class=\"synStatement\">+<\/span><span class=\"synSpecial\">(<\/span><span class=\"synConstant\">1<\/span><span class=\"synStatement\">-<\/span>S0<span class=\"synSpecial\">))<\/span><span class=\"synStatement\">\/<\/span><span class=\"synConstant\">2<\/span><span class=\"synSpecial\">)<\/span>\n<span class=\"synTodo\">NOTE<\/span> <span class=\"synStatement\">&lt;-<\/span> <span class=\"synConstant\">\"n is number in *each* group\"<\/span>\nMETHOD <span class=\"synStatement\">&lt;-<\/span> <span class=\"synConstant\">\"Sample Size of Cox Model (noninferiority)\"<\/span>\n<span class=\"synIdentifier\">structure<\/span><span class=\"synSpecial\">(<\/span>\n<span class=\"synType\">list<\/span><span class=\"synSpecial\">(<\/span>\n<span class=\"synConstant\">\"Death (Freedman)\"<\/span> <span class=\"synStatement\">=<\/span> dF<span class=\"synSpecial\">,<\/span>\n<span class=\"synConstant\">\"Number (Freedman)\"<\/span> <span class=\"synStatement\">=<\/span> nF<span class=\"synSpecial\">,<\/span>\n<span class=\"synConstant\">\"Death (Schoenfeld)\"<\/span> <span class=\"synStatement\">=<\/span> dS<span class=\"synSpecial\">,<\/span>\n<span class=\"synConstant\">\"Number(Schoenfeld)\"<\/span> <span class=\"synStatement\">=<\/span> nS<span class=\"synSpecial\">,<\/span>\n<span class=\"synConstant\">\"Survival trt(S1)\"<\/span> <span class=\"synStatement\">=<\/span> S1<span class=\"synSpecial\">,<\/span>\n<span class=\"synConstant\">\"Survival ctl(S0)\"<\/span> <span class=\"synStatement\">=<\/span> S0<span class=\"synSpecial\">,<\/span>\n<span class=\"synConstant\">\"Noninf. margin\"<\/span><span class=\"synStatement\">=<\/span> Delta.S0<span class=\"synSpecial\">,<\/span>\n<span class=\"synConstant\">\"Hazard trt(H1)\"<\/span> <span class=\"synStatement\">=<\/span> H1<span class=\"synSpecial\">,<\/span>\n<span class=\"synConstant\">\"Hazard ctl(H0)\"<\/span> <span class=\"synStatement\">=<\/span> H0<span class=\"synSpecial\">,<\/span>\n<span class=\"synConstant\">\"H0 w\/ margin\"<\/span> <span class=\"synStatement\">=<\/span> H0.prime<span class=\"synSpecial\">,<\/span>\n<span class=\"synConstant\">\"Hazard ratio(HR)\"<\/span> <span class=\"synStatement\">=<\/span> HR<span class=\"synSpecial\">,<\/span>\n<span class=\"synConstant\">\"HR w\/ margin\"<\/span> <span class=\"synStatement\">=<\/span> HR.prime<span class=\"synSpecial\">,<\/span>\n<span class=\"synConstant\">\"Follow up(y)\"<\/span> <span class=\"synStatement\">=<\/span> t<span class=\"synSpecial\">,<\/span>\nsig.level <span class=\"synStatement\">=<\/span> sig.level<span class=\"synSpecial\">,<\/span>\npower <span class=\"synStatement\">=<\/span> power<span class=\"synSpecial\">,<\/span>\nalternative <span class=\"synStatement\">=<\/span> alternative<span class=\"synSpecial\">,<\/span>\nnote <span class=\"synStatement\">=<\/span> <span class=\"synTodo\">NOTE<\/span><span class=\"synSpecial\">,<\/span>\nmethod <span class=\"synStatement\">=<\/span> METHOD<span class=\"synSpecial\">),<\/span>\nclass <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">\"power.htest\"<\/span><span class=\"synSpecial\">)<\/span>\n<span class=\"synSpecial\">}<\/span>\n<\/code><\/pre>\n\n\n\n<p>\u975e\u52a3\u6027\u30de\u30fc\u30b8\u30f3\u306e\u8003\u3048\u65b9\u306f\u3053\u3061\u3089\u3092\u53c2\u7167\u3002<\/p>\n\n\n<div class=\"swell-block-postLink\">\t\t\t<div class=\"p-blogCard -internal\" data-type=\"type1\" data-onclick=\"clickLink\">\n\t\t\t\t<div class=\"p-blogCard__inner\">\n\t\t\t\t\t<span class=\"p-blogCard__caption\">\u3042\u308f\u305b\u3066\u8aad\u307f\u305f\u3044<\/span>\n\t\t\t\t\t<div class=\"p-blogCard__thumb c-postThumb\"><figure class=\"c-postThumb__figure\"><img decoding=\"async\" src=\"https:\/\/best-biostatistics.com\/toukei-er\/wp-content\/uploads\/2024\/08\/1920x1080-video-Excel-300x169.jpg\" alt=\"\" class=\"c-postThumb__img u-obf-cover\" width=\"320\" height=\"180\"><\/figure><\/div>\t\t\t\t\t<div class=\"p-blogCard__body\">\n\t\t\t\t\t\t<a class=\"p-blogCard__title\" href=\"https:\/\/best-biostatistics.com\/toukei-er\/entry\/what-is-and-how-to-do-non-inferiority-test\/\">\u975e\u52a3\u6027\u30de\u30fc\u30b8\u30f3\u306e\u6c7a\u3081\u65b9\u3068 R \u3067\u975e\u52a3\u6027\u691c\u5b9a\u3092\u5b9f\u884c\u3059\u308b\u65b9\u6cd5<\/a>\n\t\t\t\t\t\t<span class=\"p-blogCard__excerpt\">\u3044\u307e\u307e\u3067\u306e\u65b9\u6cd5\u3068\u6bd4\u3079\u3066\u3001\u683c\u6bb5\u306b\u3044\u3044\u3068\u304b\u3001\u969b\u7acb\u3063\u3066\u3044\u3044\u3068\u304b\u3001\u3058\u3083\u306a\u304f\u3066\u3082\u3044\u3044\u5834\u5408\u304c\u3042\u308b\u3002 \u30c0\u30e1\u3058\u3083\u306a\u3051\u308c\u3070\u3044\u3044\u3002 \u52a3\u3063\u3066\u3044\u306a\u3051\u308c\u3070\u3044\u3044\u3002 \u52a3\u3063\u3066\u3044\u306a\u3051\u308c\u3070\u3044\u3044\u3068\u3044&#8230;<\/span>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\n\n\n\n\n<p>\u89b3\u5bdf\u671f\u95935\u5e74\u3001\u6cbb\u7642\u7fa4\u306e\u751f\u5b58\u7387\u304c80%\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u306e\u751f\u5b58\u7387\u304c65%\u3001\u975e\u52a3\u6027\u30de\u30fc\u30b8\u30f3\u306f\u76f8\u5bfe10%\u3067\u30010.065\uff1d6.5%\u3068\u3057\u3066\u3001\u4e21\u5074\u691c\u5b9a\u3068\u3059\u308b\u3068\u3001<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Freedman\u306e\u65b9\u6cd5\u3067\u306f\u3001\u4e00\u7fa484\u4f8b\u5fc5\u8981\u3001<\/li>\n\n\n\n<li>Schoenfeld\u306e\u65b9\u6cd5\u3067\u306f\u3001\u4e00\u7fa475\u4f8b\u5fc5\u8981<\/li>\n<\/ul>\n\n\n\n<p>\u3068\u8a08\u7b97\u3055\u308c\u308b\u3002<\/p>\n\n\n\n<pre class=\"wp-block-code\"><code><span class=\"synStatement\">&gt;<\/span> <span class=\"synIdentifier\">sample.size.cox.noninf<\/span><span class=\"synSpecial\">(<\/span>t<span class=\"synStatement\">=<\/span><span class=\"synConstant\">5<\/span><span class=\"synSpecial\">,<\/span> S1<span class=\"synStatement\">=<\/span><span class=\"synConstant\">0.8<\/span><span class=\"synSpecial\">,<\/span> S0<span class=\"synStatement\">=<\/span><span class=\"synConstant\">0.65<\/span><span class=\"synSpecial\">,<\/span> Delta.S0<span class=\"synStatement\">=<\/span><span class=\"synConstant\">0.065<\/span><span class=\"synSpecial\">,<\/span> alternative<span class=\"synStatement\">=<\/span><span class=\"synConstant\">\"two.sided\"<\/span><span class=\"synSpecial\">)<\/span>\nSample Size of Cox <span class=\"synIdentifier\">Model <\/span><span class=\"synSpecial\">(<\/span>noninferiority<span class=\"synSpecial\">)<\/span>\n<span class=\"synIdentifier\">Death <\/span><span class=\"synSpecial\">(<\/span>Freedman<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">23.09411<\/span>\n<span class=\"synIdentifier\">Number <\/span><span class=\"synSpecial\">(<\/span>Freedman<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">83.97858<\/span>\n<span class=\"synIdentifier\">Death <\/span><span class=\"synSpecial\">(<\/span>Schoenfeld<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">20.42905<\/span>\n<span class=\"synIdentifier\">Number<\/span><span class=\"synSpecial\">(<\/span>Schoenfeld<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">74.28746<\/span>\nSurvival <span class=\"synIdentifier\">trt<\/span><span class=\"synSpecial\">(<\/span>S1<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.8<\/span>\nSurvival <span class=\"synIdentifier\">ctl<\/span><span class=\"synSpecial\">(<\/span>S0<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.65<\/span>\nNoninf. margin <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.065<\/span>\nHazard <span class=\"synIdentifier\">trt<\/span><span class=\"synSpecial\">(<\/span>H1<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.04462871<\/span>\nHazard <span class=\"synIdentifier\">ctl<\/span><span class=\"synSpecial\">(<\/span>H0<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.08615658<\/span>\nH0 w<span class=\"synStatement\">\/<\/span> margin <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.1072287<\/span>\nHazard <span class=\"synIdentifier\">ratio<\/span><span class=\"synSpecial\">(<\/span>HR<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.5179954<\/span>\nHR w<span class=\"synStatement\">\/<\/span> margin <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.4162012<\/span>\nFollow <span class=\"synIdentifier\">up<\/span><span class=\"synSpecial\">(<\/span>y<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">5<\/span>\nsig.level <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.05<\/span>\npower <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.8<\/span>\nalternative <span class=\"synStatement\">=<\/span> two.sided\nNOTE<span class=\"synSpecial\">:<\/span> n is number <span class=\"synStatement\">in<\/span> <span class=\"synStatement\">*<\/span>each<span class=\"synStatement\">*<\/span> group\n<\/code><\/pre>\n\n\n\n<p>Freedman\u306e\u65b9\u6cd5\u306fSchoenfeld\u306e\u65b9\u6cd5\u3088\u308a\u3044\u3064\u3082\u5927\u304d\u3081\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u306b\u306a\u308b\u3002<\/p>\n\n\n\n<p>Schoenfeld\u5f0f\u306e\u7d50\u679c\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u3092\u904e\u5c0f\u8a55\u4fa1\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u6307\u6458\u304c\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u5b89\u5168\u78ba\u5b9f\u306b\u898b\u7a4d\u3082\u308b\u306a\u3089Freedman\u306e\u65b9\u6cd5\u3001\u75c7\u4f8b\u304c\u3042\u307e\u308a\u96c6\u307e\u308a\u305d\u3046\u3067\u306a\u3044\u5834\u5408\u306fSchoenfeld\u306e\u65b9\u6cd5\u3068\u3044\u3046\u5224\u65ad\u57fa\u6e96\u3067\u3088\u3044\u3068\u601d\u3046\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97-\u751f\u5b58\u6642\u9593\u30c7\u30fc\u30bf\u306e\u5834\u5408-\u4f8b-2\">\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97 \u751f\u5b58\u6642\u9593\u30c7\u30fc\u30bf\u306e\u5834\u5408 \u4f8b 2<\/h2>\n\n\n\n<p>\u8a66\u9a13\u30c7\u30b6\u30a4\u30f3\u306f\u8a66\u9a13\u85ac\u3068\u5bfe\u7167\u85ac\u306e\uff12\u6295\u4e0e\u7fa4\u306e\u7121\u4f5c\u70ba\u6bd4\u8f03\u8a66\u9a13\u3002<\/p>\n\n\n\n<p>\u8ffd\u8de1\u671f\u95935\u5e74\u3067\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306fOverall survival\u3002<\/p>\n\n\n\n<p>\u8a66\u9a13\u85ac\u306eOverall survival\u306e\u975e\u52a3\u6027\u3092\u8a3c\u660e\u3059\u308b\u305f\u3081\u306e\u5fc5\u8981\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u3092\u7b97\u51fa\u3057\u305f\u3044\u3002<\/p>\n\n\n\n<p>\u60f3\u5b9a\u3055\u308c\u308b5\u5e74\u751f\u5b58\u7387\u306f\u4e21\u7fa4\u3068\u308295%\u3067\u3001\u975e\u52a3\u6027\u30de\u30fc\u30b8\u30f3\u306f5%\u306b\u8a2d\u5b9a\u3001\u7247\u5074\u03b1=0.05\u3001\u691c\u51fa\u7387=0.8\u3092\u8003\u3048\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<p>\u5b9f\u969b\u306b\u8a08\u7b97\u3057\u3066\u307f\u308b\u3068\u3001Freedman\u5f0f\u3067\u306f\u3001520\u4f8b\u5fc5\u8981\u3068\u8a08\u7b97\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<p>Schoenfeld\u5f0f\u3067\u306f\u3001478\u4f8b\u5fc5\u8981\u3068\u8a08\u7b97\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<pre class=\"wp-block-code\"><code><span class=\"synStatement\">&gt;<\/span> <span class=\"synIdentifier\">sample.size.cox.noninf<\/span><span class=\"synSpecial\">(<\/span>t<span class=\"synStatement\">=<\/span><span class=\"synConstant\">5<\/span><span class=\"synSpecial\">,<\/span> S1<span class=\"synStatement\">=<\/span><span class=\"synConstant\">0.95<\/span><span class=\"synSpecial\">,<\/span> S0<span class=\"synStatement\">=<\/span><span class=\"synConstant\">0.95<\/span><span class=\"synSpecial\">,<\/span> Delta.S0<span class=\"synStatement\">=<\/span><span class=\"synConstant\">0.05<\/span><span class=\"synSpecial\">,<\/span> alternative<span class=\"synStatement\">=<\/span><span class=\"synConstant\">\"one.sided\"<\/span><span class=\"synSpecial\">)<\/span>\nSample Size of Cox <span class=\"synIdentifier\">Model <\/span><span class=\"synSpecial\">(<\/span>noninferiority<span class=\"synSpecial\">)<\/span>\n<span class=\"synIdentifier\">Death <\/span><span class=\"synSpecial\">(<\/span>Freedman<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">25.95087<\/span>\n<span class=\"synIdentifier\">Number <\/span><span class=\"synSpecial\">(<\/span>Freedman<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">519.0175<\/span>\n<span class=\"synIdentifier\">Death <\/span><span class=\"synSpecial\">(<\/span>Schoenfeld<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">23.86386<\/span>\n<span class=\"synIdentifier\">Number<\/span><span class=\"synSpecial\">(<\/span>Schoenfeld<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">477.2773<\/span>\nSurvival <span class=\"synIdentifier\">trt<\/span><span class=\"synSpecial\">(<\/span>S1<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.95<\/span>\nSurvival <span class=\"synIdentifier\">ctl<\/span><span class=\"synSpecial\">(<\/span>S0<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.95<\/span>\nNoninf. margin <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.05<\/span>\nHazard <span class=\"synIdentifier\">trt<\/span><span class=\"synSpecial\">(<\/span>H1<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.01025866<\/span>\nHazard <span class=\"synIdentifier\">ctl<\/span><span class=\"synSpecial\">(<\/span>H0<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.01025866<\/span>\nH0 w<span class=\"synStatement\">\/<\/span> margin <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.0210721<\/span>\nHazard <span class=\"synIdentifier\">ratio<\/span><span class=\"synSpecial\">(<\/span>HR<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">1<\/span>\nHR w<span class=\"synStatement\">\/<\/span> margin <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.486836<\/span>\nFollow <span class=\"synIdentifier\">up<\/span><span class=\"synSpecial\">(<\/span>y<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">5<\/span>\nsig.level <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.05<\/span>\npower <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.8<\/span>\nalternative <span class=\"synStatement\">=<\/span> one.sided\nNOTE<span class=\"synSpecial\">:<\/span> n is number <span class=\"synStatement\">in<\/span> <span class=\"synStatement\">*<\/span>each<span class=\"synStatement\">*<\/span> group\n<\/code><\/pre>\n\n\n\n<p>\u304b\u306a\u308a\u81a8\u5927\u306a\u75c7\u4f8b\u6570\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p>\u3053\u3046\u3044\u3046\u5834\u5408\u306f\u3001\u60f3\u5b9a\u306b\u7121\u7406\u304c\u3042\u308b\u3068\u8003\u3048\u305f\u307b\u3046\u304c\u826f\u3044\u3002<\/p>\n\n\n\n<div id=\"biost-2577030007\" class=\"biost- biost-entity-placement\"><p style=\"text-align: center;\"><span style=\"font-size: 20px;\"><strong><a href=\"https:\/\/best-biostatistics.com\/kmhl\">\uff1e\uff1e\u3082\u3046\u7d71\u8a08\u3067\u60a9\u3080\u306e\u306f\u7d42\u308f\u308a\u306b\u3057\u307e\u305b\u3093\u304b\uff1f\u00a0<\/a><\/strong><\/span><\/p>\r\n<a href=\"https:\/\/best-biostatistics.com\/kmhl\"><img class=\"aligncenter wp-image-2794 size-full\" src=\"https:\/\/best-biostatistics.com\/wp\/wp-content\/uploads\/2023\/11\/bn_r_03.png\" alt=\"\" width=\"500\" height=\"327\" \/><\/a>\r\n<p style=\"text-align: center;\"><span style=\"color: #ff0000; font-size: 20px;\"><strong><span class=\"marker2\">\u21911\u4e07\u4eba\u4ee5\u4e0a\u306e\u533b\u7642\u5f93\u4e8b\u8005\u304c\u8cfc\u8aad\u4e2d<\/span><\/strong><\/span><\/p><\/div><h2 class=\"wp-block-heading\" id=\"\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97-\u751f\u5b58\u6642\u9593\u30c7\u30fc\u30bf\u306e\u5834\u5408-\u4f8b-3-\u8ffd\u8de1\u671f\u9593\u3092\u5ef6\u9577\u3059\u308b\">\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97 \u751f\u5b58\u6642\u9593\u30c7\u30fc\u30bf\u306e\u5834\u5408 \u4f8b 3 \u8ffd\u8de1\u671f\u9593\u3092\u5ef6\u9577\u3059\u308b<\/h2>\n\n\n\n<p>\u8ffd\u8de1\u671f\u9593\u309210\u5e74\u306b\u3059\u308b\u3068\u3069\u3046\u306a\u308b\u304b\uff1f<\/p>\n\n\n\n<p>\u305d\u306e\u4ed6\u306e\u6761\u4ef6\u306f\u540c\u3058\u3067\u3001\u60f3\u5b9a\u3055\u308c\u308b5\u5e74\u751f\u5b58\u7387\u306f\u4e21\u7fa4\u3068\u308295%\u3067\u3001\u975e\u52a3\u6027\u30de\u30fc\u30b8\u30f3\u306f5%\u306b\u8a2d\u5b9a\u3001\u7247\u5074\u03b1=0.05\u3001\u691c\u51fa\u7387=0.8\u3068\u3059\u308b\u3002<\/p>\n\n\n\n<p>\u308f\u304b\u3063\u3066\u3044\u308b\u751f\u5b58\u7387\u304c5\u5e74\u751f\u5b58\u7387\u306a\u306e\u3067\u300110\u5e74\u307e\u3067\u89b3\u5bdf\u3057\u305f\u6642\u306e\u751f\u5b58\u7387\u3092\u6307\u6570\u95a2\u6570\u3092\u4f7f\u3063\u3066\u4e88\u6e2c\u3059\u308b\u3002<\/p>\n\n\n\n<pre class=\"wp-block-code\"><code><span class=\"synComment\">## 5\u5e74\u751f\u5b58\u7387\u3092R\u3068\u3059\u308b<\/span>\nR <span class=\"synStatement\">&lt;-<\/span> <span class=\"synConstant\">0.95<\/span>\n<span class=\"synComment\">## 1\u5e74\u6b7b\u4ea1\u7387\u3092\u8a08\u7b97<\/span>\n<span class=\"synSpecial\">(<\/span>r <span class=\"synStatement\">&lt;-<\/span> <span class=\"synConstant\">1<\/span><span class=\"synStatement\">-<\/span>R<span class=\"synStatement\">^<\/span><span class=\"synSpecial\">(<\/span><span class=\"synConstant\">1<\/span><span class=\"synStatement\">\/<\/span><span class=\"synConstant\">5<\/span><span class=\"synSpecial\">))<\/span>\n<span class=\"synComment\">## 10\u5e74\u751f\u5b58\u7387\u3092\u8a08\u7b97<\/span>\n<span class=\"synSpecial\">(<\/span><span class=\"synConstant\">1<\/span><span class=\"synStatement\">-<\/span>r<span class=\"synSpecial\">)<\/span><span class=\"synStatement\">^<\/span><span class=\"synConstant\">10<\/span>\n<\/code><\/pre>\n\n\n\n<p>\u7d50\u679c\u300110\u5e74\u751f\u5b58\u7387\u306f0.9025\uff0890.25%\uff09\u3068\u8a08\u7b97\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<pre class=\"wp-block-code\"><code><span class=\"synStatement\">&gt;<\/span> <span class=\"synComment\">## 5\u5e74\u751f\u5b58\u7387\u3092R\u3068\u3059\u308b<\/span>\n<span class=\"synStatement\">&gt;<\/span> R <span class=\"synStatement\">&lt;-<\/span> <span class=\"synConstant\">0.95<\/span>\n<span class=\"synStatement\">&gt;<\/span> <span class=\"synComment\">## 1\u5e74\u6b7b\u4ea1\u7387\u3092\u8a08\u7b97<\/span>\n<span class=\"synStatement\">&gt;<\/span> <span class=\"synSpecial\">(<\/span>r <span class=\"synStatement\">&lt;-<\/span> <span class=\"synConstant\">1<\/span><span class=\"synStatement\">-<\/span>R<span class=\"synStatement\">^<\/span><span class=\"synSpecial\">(<\/span><span class=\"synConstant\">1<\/span><span class=\"synStatement\">\/<\/span><span class=\"synConstant\">5<\/span><span class=\"synSpecial\">))<\/span>\n<span class=\"synSpecial\">&#91;<\/span><span class=\"synConstant\">1<\/span><span class=\"synSpecial\">]<\/span> <span class=\"synConstant\">0.01020622<\/span>\n<span class=\"synStatement\">&gt;<\/span> <span class=\"synComment\">## 10\u5e74\u751f\u5b58\u7387\u3092\u8a08\u7b97<\/span>\n<span class=\"synStatement\">&gt;<\/span> <span class=\"synSpecial\">(<\/span><span class=\"synConstant\">1<\/span><span class=\"synStatement\">-<\/span>r<span class=\"synSpecial\">)<\/span><span class=\"synStatement\">^<\/span><span class=\"synConstant\">10<\/span>\n<span class=\"synSpecial\">&#91;<\/span><span class=\"synConstant\">1<\/span><span class=\"synSpecial\">]<\/span> <span class=\"synConstant\">0.9025<\/span>\n<\/code><\/pre>\n\n\n\n<p>\u305d\u308c\u3067\u306f\u300110\u5e74\u751f\u5b58\u7387 0.9025 \u3092\u4f7f\u3063\u3066\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u3092\u8a08\u7b97\u3057\u3066\u307f\u308b\u3002<\/p>\n\n\n\n<p>\u7d50\u679c\u306f\u3001Freedman\u5f0f\u3067671\u4f8b\u3001Schoenfeld\u5f0f\u3067650\u4f8b\u3068\u8a08\u7b97\u3055\u308c\u305f\u3002<\/p>\n\n\n\n<p>5\u5e74\u89b3\u5bdf\u306e\u3068\u304d\u3088\u308a\u3082\u3001\u305f\u304f\u3055\u3093\u306e\u4eba\u6570\u304c\u5fc5\u8981\u306b\u306a\u3063\u305f\u3002<\/p>\n\n\n\n<pre class=\"wp-block-code\"><code><span class=\"synStatement\">&gt;<\/span> <span class=\"synIdentifier\">sample.size.cox.noninf<\/span><span class=\"synSpecial\">(<\/span>t<span class=\"synStatement\">=<\/span><span class=\"synConstant\">10<\/span><span class=\"synSpecial\">,<\/span> S1<span class=\"synStatement\">=<\/span><span class=\"synConstant\">0.9025<\/span><span class=\"synSpecial\">,<\/span> S0<span class=\"synStatement\">=<\/span><span class=\"synConstant\">0.9025<\/span><span class=\"synSpecial\">,<\/span> Delta.S0<span class=\"synStatement\">=<\/span><span class=\"synConstant\">0.05<\/span><span class=\"synSpecial\">,<\/span> alternative<span class=\"synStatement\">=<\/span><span class=\"synConstant\">\"one.sided\"<\/span><span class=\"synSpecial\">)<\/span>\nSample Size of Cox <span class=\"synIdentifier\">Model <\/span><span class=\"synSpecial\">(<\/span>noninferiority<span class=\"synSpecial\">)<\/span>\n<span class=\"synIdentifier\">Death <\/span><span class=\"synSpecial\">(<\/span>Freedman<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">65.40619<\/span>\n<span class=\"synIdentifier\">Number <\/span><span class=\"synSpecial\">(<\/span>Freedman<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">670.8327<\/span>\n<span class=\"synIdentifier\">Death <\/span><span class=\"synSpecial\">(<\/span>Schoenfeld<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">63.33536<\/span>\n<span class=\"synIdentifier\">Number<\/span><span class=\"synSpecial\">(<\/span>Schoenfeld<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">649.5934<\/span>\nSurvival <span class=\"synIdentifier\">trt<\/span><span class=\"synSpecial\">(<\/span>S1<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.9025<\/span>\nSurvival <span class=\"synIdentifier\">ctl<\/span><span class=\"synSpecial\">(<\/span>S0<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.9025<\/span>\nNoninf. margin <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.05<\/span>\nHazard <span class=\"synIdentifier\">trt<\/span><span class=\"synSpecial\">(<\/span>H1<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.01025866<\/span>\nHazard <span class=\"synIdentifier\">ctl<\/span><span class=\"synSpecial\">(<\/span>H0<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.01025866<\/span>\nH0 w<span class=\"synStatement\">\/<\/span> margin <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.01595821<\/span>\nHazard <span class=\"synIdentifier\">ratio<\/span><span class=\"synSpecial\">(<\/span>HR<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">1<\/span>\nHR w<span class=\"synStatement\">\/<\/span> margin <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.6428453<\/span>\nFollow <span class=\"synIdentifier\">up<\/span><span class=\"synSpecial\">(<\/span>y<span class=\"synSpecial\">)<\/span> <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">10<\/span>\nsig.level <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.05<\/span>\npower <span class=\"synStatement\">=<\/span> <span class=\"synConstant\">0.8<\/span>\nalternative <span class=\"synStatement\">=<\/span> one.sided\nNOTE<span class=\"synSpecial\">:<\/span> n is number <span class=\"synStatement\">in<\/span> <span class=\"synStatement\">*<\/span>each<span class=\"synStatement\">*<\/span> group\n<\/code><\/pre>\n\n\n\n<p>\u8a66\u9a13\u7fa4\u3068\u5bfe\u7167\u7fa4\u306e\u751f\u5b58\u7387\u306b\u5dee\u304c\u306a\u3044\u5834\u5408\u3001\u52a3\u3089\u306a\u3044\u3053\u3068\u3092\u793a\u3059\u306e\u306f\u7c21\u5358\u3060\u308d\u3046\u3068\u601d\u3046\u304b\u3082\u3057\u308c\u306a\u3044\u304c\u3001\u7d71\u8a08\u5b66\u7684\u306b\u975e\u52a3\u6027\u3092\u8a3c\u660e\u3059\u308b\u306b\u306f\u304b\u306a\u308a\u5927\u5909\u3067\u3001\u5de8\u5927\u306a\u8a66\u9a13\u306b\u306a\u308b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97-\u751f\u5b58\u6642\u9593\u30c7\u30fc\u30bf\u306e\u5834\u5408-\u30a8\u30af\u30bb\u30eb\u3067\">\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97 \u751f\u5b58\u6642\u9593\u30c7\u30fc\u30bf\u306e\u5834\u5408 \u30a8\u30af\u30bb\u30eb\u3067<\/h2>\n\n\n\n<p>\u30a8\u30af\u30bb\u30eb\u3067\u8a08\u7b97\u3067\u304d\u308b\u3088\u3046\u306b\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3088\u3051\u308c\u3070\u4e0b\u8a18\u304b\u3089\u3069\u3046\u305e\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/happyhappygk.base.ec\/items\/26107247\">https:\/\/happyhappygk.base.ec\/items\/26107247<\/a><\/p>\n\n\n\n\n\n\n\n<p>\u30a8\u30af\u30bb\u30eb\u30d5\u30a1\u30a4\u30eb\u306e\u4f7f\u3044\u65b9\u89e3\u8aac\u52d5\u753b\u3002<\/p>\n\n\n\n<p>\u3088\u304b\u3063\u305f\u3089\u3053\u3061\u3089\u3082\u3069\u3046\u305e\u3002<\/p>\n\n\n\n<p><iframe width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/6xHYLPiKxJQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen=\"allowfullscreen\" title=\"\u30b3\u30c3\u30af\u30b9\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u975e\u52a3\u6027\u8a66\u9a13 \u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u3010\u30a8\u30af\u30bb\u30eb\u3067\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u3011\"><\/iframe><cite class=\"hatena-citation\"><a href=\"https:\/\/youtu.be\/6xHYLPiKxJQ\">youtu.be<\/a><\/cite><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u307e\u3068\u3081\">\u307e\u3068\u3081<\/h2>\n\n\n\n<p>\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u3092\u751f\u5b58\u6642\u9593\u30c7\u30fc\u30bf\u306e\u5834\u5408\u3092\u89e3\u8aac\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u53c2\u8003\u306b\u306a\u308c\u3070\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u53c2\u8003\u6587\u732e\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n\n<p>\u6d5c\u7530\uff06\u85e4\u4e95\u3000\u751f\u5b58\u6642\u9593\u89e3\u6790\u306b\u304a\u3051\u308b\u75c7\u4f8b\u6570\u8a2d\u8a08<br>\u7b2c22\u56de\u3000\u65e5\u672cSAS\u30e6\u30fc\u30b6\u30fc\u4f1a\u7dcf\u4f1a\u304a\u3088\u3073\u7814\u7a76\u767a\u8868\u4f1a\u3000\u8ad6\u6587\u96c6<br>2003\u5e747\u670831\u65e5\uff5e8\u67081\u65e5\u3000\u6771\u4eac<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97-\u751f\u5b58\u6642\u9593\u30c7\u30fc\u30bf\u306e\u5834\u5408-EZR\u3067\u52d5\u753b\">\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97 \u751f\u5b58\u6642\u9593\u30c7\u30fc\u30bf\u306e\u5834\u5408 EZR\u3067\u3010\u52d5\u753b\u3011<\/h2>\n\n\n\n<p>EZR\u3067\u306e\u8a08\u7b97\u306e\u4ed5\u65b9\u89e3\u8aac\u52d5\u753b\u3002<\/p>\n\n\n\n<p>\u3088\u3051\u308c\u3070\u3069\u3046\u305e\u3002<\/p>\n\n\n\n<p><iframe width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/IJlnHdE1bJk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen=\"allowfullscreen\" title=\"EZR\u3067Cox\u306e\u975e\u52a3\u6027\u8a66\u9a13\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97\u3010\u7121\u6599\u7d71\u8a08\u30bd\u30d5\u30c8EZR\u3067\u7c21\u5358\u7d71\u8a08\u3011\"><\/iframe><cite class=\"hatena-citation\"><a href=\"https:\/\/youtu.be\/IJlnHdE1bJk\">youtu.be<\/a><\/cite><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u304a\u3059\u3059\u3081\u66f8\u7c4d\">\u304a\u3059\u3059\u3081\u66f8\u7c4d<\/h2>\n\n\n\n<p>EZR\u516c\u5f0f\u30de\u30cb\u30e5\u30a2\u30eb<\/p>\n\n\n\n<div class=\"hatena-asin-detail\"><a href=\"https:\/\/www.amazon.co.jp\/dp\/449810918X?tag=ttyotani-22&amp;linkCode=ogi&amp;th=1&amp;psc=1\" class=\"hatena-asin-detail-image-link\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/m.media-amazon.com\/images\/I\/51ouXcnW2-L._SL500_.jpg\" class=\"hatena-asin-detail-image\" alt=\"EZR\u3067\u3084\u3055\u3057\u304f\u5b66\u3076\u7d71\u8a08\u5b66 \u6539\u8a023\u7248 \u301cEBM\u306e\u5b9f\u8df5\u304b\u3089\u81e8\u5e8a\u7814\u7a76\u307e\u3067\u301c\" title=\"EZR\u3067\u3084\u3055\u3057\u304f\u5b66\u3076\u7d71\u8a08\u5b66 \u6539\u8a023\u7248 \u301cEBM\u306e\u5b9f\u8df5\u304b\u3089\u81e8\u5e8a\u7814\u7a76\u307e\u3067\u301c\"><\/a>\n<div class=\"hatena-asin-detail-info\">\n<p class=\"hatena-asin-detail-title\"><a href=\"https:\/\/www.amazon.co.jp\/dp\/449810918X?tag=ttyotani-22&amp;linkCode=ogi&amp;th=1&amp;psc=1\" target=\"_blank\" rel=\"noopener\">EZR\u3067\u3084\u3055\u3057\u304f\u5b66\u3076\u7d71\u8a08\u5b66 \u6539\u8a023\u7248 \u301cEBM\u306e\u5b9f\u8df5\u304b\u3089\u81e8\u5e8a\u7814\u7a76\u307e\u3067\u301c<\/a><\/p>\n<ul class=\"hatena-asin-detail-meta\">\n<li><span class=\"hatena-asin-detail-label\">\u4f5c\u8005:<\/span><a href=\"https:\/\/d.hatena.ne.jp\/keyword\/%BF%C0%C5%C4%20%C1%B1%BF%AD\" class=\"keyword\">\u795e\u7530 \u5584\u4f38<\/a><\/li>\n<li>\u4e2d\u5916\u533b\u5b66\u793e<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.amazon.co.jp\/dp\/449810918X?tag=ttyotani-22&amp;linkCode=ogi&amp;th=1&amp;psc=1\" class=\"asin-detail-buy\" target=\"_blank\" rel=\"noopener\">Amazon<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u8a08\u7b97 \u751f\u5b58\u6642\u9593\u30c7\u30fc\u30bf\u306e\u5834\u5408<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[4,5,30,21,16,133],"tags":[],"class_list":["post-521","post","type-post","status-publish","format-standard","hentry","category-ezr","category-r","category-30","category-21","category-16","category-133"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts\/521","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/comments?post=521"}],"version-history":[{"count":3,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts\/521\/revisions"}],"predecessor-version":[{"id":2864,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/posts\/521\/revisions\/2864"}],"wp:attachment":[{"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/media?parent=521"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/categories?post=521"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/best-biostatistics.com\/toukei-er\/wp-json\/wp\/v2\/tags?post=521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}